Evidence map›Paper›PMID 40287494›Full record

ArticleScientific reports2025

A deep learning-based multimodal medical imaging model for breast cancer screening.

Junwei Chen, Teng Pan, Zhengjie Zhu, Lijue Liu, Ning Zhao, Xue Feng, Weilong Zhang, Yuesong Wu, Cuidan Cai, Xiaojin Luo and 11 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  7. 3D Medical Image Segmentation with 3D Modelling.Bioengineering (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Junwei Chen *School of Automation, Central South University, Changsha, Hunan, 410083, China.
Teng Pan *Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Zhengjie Zhu *Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Lijue LiuSchool of Automation, Central South University, Changsha, Hunan, 410083, China. ljliu@csu.edu.cn.
Ning ZhaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Xue FengDepartment of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, 300222, China.
Weilong ZhangDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, 100191, China.
Yuesong WuClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Diagnosis and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, School of Medicine, Chongqing, 404100, China.
Cuidan CaiLonggang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Xiaojin LuoLonggang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Bihai LinLonggang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Xuewei WangLonggang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Qiaoru YeThe Third People's Hospital of Longgang District Shenzhen, Shenzhen, 518112, China.
Rui GaoLonggang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Zizhen ZhouLonggang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Richard BeatsonRichard Dimbleby Department of Cancer Research, Comprehensive Cancer Centre, Kings College London, London, SE1 1UL, United Kingdom.
Jin TangSchool of Automation, Central South University, Changsha, Hunan, 410083, China.
Ruijie MingDepartment of Oncology, Chongqing University Three Gorges Hospital, Chongqing, 404010, China.
Dan WangRichard Dimbleby Laboratory of Cancer Research, Randall Division and Division of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
Jinhai DengClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Diagnosis and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, School of Medicine, Chongqing, 404100, China. jinhaideng_kcl@163.com.
Guanglin ZhouLonggang District Maternity & Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China. zgl3822@lg.gov.cn.

Funding

Chongqing Natural Science Foundation Grant No. CSTB2024NSCQ- MSX0761Hunan Natural Science Foundation Grant No. 2025JJ50396Research Initiation Funding Project of Longgang District Maternity & Child Healthcare Hospital of Shenzhen City Grant No. Y2024013Scientific Research Project of Xiang Jiang Lab Grant No. 23XJ2002
6 · The paper itself

Abstract

In existing breast cancer prediction research, most models rely solely on a single type of imaging data, which limits their performance. To overcome this limitation, the present study explores breast cancer prediction models based on multimodal medical images (mammography and ultrasound images) and compares them with single-modal models. We collected medical imaging data from 790 patients, including 2,235 mammography images and 1,348 ultrasound images, and conducted a comparison using six deep learning classification models to identify the best model for constructing the multimodal classification model. Performance was evaluated using metrics such as area under the receiver operating characteristic curve (AUC), sensitivity, specificity, precision, and accuracy to compare the multimodal and single-modal classification models. Experimental results demonstrate that the multimodal classification model outperforms single-modal models in terms of specificity (96.41% (95% CI:93.10%-99.72%)), accuracy (93.78% (95% CI:87.67%-99.89%)), precision (83.66% (95% CI:76.27%-91.05%)), and AUC (0.968 (95% CI:0.947-0.989)), while single-modal models excel in sensitivity. Additionally, heatmap visualization was used to further validate the classification performance of the multimodal model. In conclusion, our multimodal classification model shows strong potential in breast cancer screening tasks, effectively assisting physicians in improving screening accuracy.

Indexed as

Breast NeoplasmsDeep LearningEarly Detection of CancerMultimodal ImagingAdultAgedArea Under CurveFemaleHumansMammographyMiddle AgedROC CurveSensitivity and SpecificityDeep learningDigital mammographyMultimodalUltrasound

Identifiers

PMID40287494
PMCPMC12033348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.