Evidence map›Paper›PMID 40287492›Full record

Trial reportScientific reports2025

The efficiency of azelastine hydrochloride and fluticasone propionate nasal spray to improve PAP adherence in patients with obstructive sleep apnea.

Rachata Wongchan, Chatkarin Tepwimonpetkun, Jutarat Kitsongsermthon, Tunlanut Sapankaew, Kitiyot Yotsombut, Weasarath Chittiwan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachata WongchanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Chatkarin TepwimonpetkunDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand. chatkarin_ball@hotmail.com.
Jutarat KitsongsermthonFaculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Tunlanut SapankaewDepartment of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Kitiyot YotsombutFaculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Weasarath ChittiwanKing Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with obstructive sleep apnea (OSA) often struggle with CPAP therapy adherence. The intranasal corticosteroids (INS) alone have not significantly improved CPAP adherence but the combination drugs that faster relieved symptoms were not well studied. This study aimed to assess the combined effectiveness of INS (fluticasone propionate) and intranasal antihistamines (azelastine hydrochloride) in enhancing CPAP adherence and mitigating CPAP-induced rhinitis symptoms in OSA patients. A double-blind, randomized controlled trial with stratified random sampling was conducted at Thammasat University Hospital from March 2022 to March 2023. Participants included OSA patients undergoing CPAP treatment. The patients completed questionnaires and interviews at the baseline, the second week, and one month after starting CPAP therapy, with CPAP usage electronic data collected. Among 116 enrolled patients, most had severe OSA (78.9%), with a majority being male (56.9%). The intervention group did not significantly differ from the placebo group in terms of CPAP usage, nasal symptoms, quality of life, or side effects. Subgroup analysis showed improved CPAP adherence in the treatment group when using pressure below 15 cm H

Indexed as

Continuous Positive Airway PressureFluticasonePatient CompliancePhthalazinesSleep Apnea, ObstructiveAdministration, IntranasalAdultAgedDouble-Blind MethodDrug Therapy, CombinationFemaleHumansMaleMiddle AgedNasal SpraysQuality of LifeazelastineFluticasoneNasal SpraysPhthalazinesAzelastine hydrochloride and fluticasone propionate nasal sprayCPAP-induced rhinitisIntranasal steroidObstructive sleep apneaPositive airway pressure compliance

Identifiers

PMID40287492
PMCPMC12033272

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.