Evidence map›Paper›PMID 40287447›Full record

ArticleScientific reports2025

In-vitro assessment and characterization of anticancer, antibacterial, and antioxidant activity of diatom-derived metabolites.

Raya Bhattacharjya, Rashi Tyagi, Sangita Dey, Ankita Dutta, Anoop Kumar, Mostafa M El-Sheekh, Subha Rastogi, Nutan Kaushik, Archana Tiwari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Anticancer and Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raya BhattacharjyaDiatom Research Laboratory, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201313, India.
Rashi TyagiDiatom Research Laboratory, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201313, India.
Sangita DeyDepartment of Biotechnology, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal, 734013, India.
Ankita DuttaDepartment of Biotechnology, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal, 734013, India.
Anoop KumarDepartment of Biotechnology, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal, 734013, India.
Mostafa M El-SheekhBotany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Subha RastogiCSIR-National Botanical Research Institute, 436, Pratap Marg, Lucknow, Uttar Pradesh, 226001, India.
Nutan KaushikAmity Food and Agriculture Foundation, Amity University Uttar Pradesh, Noida, India.
Archana TiwariDiatom Research Laboratory, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201313, India. panarchana@gmail.com.

Funding

Science and Engineering Research Board CRD/2022/000595
6 · The paper itself

Abstract

Microalgae are known to produce a spectrum of highly valuable metabolites with substantial nutritional content and pharmacogenetic properties. To explore the antioxidant, antibacterial, as well as anticancer activity of five such microalgal strains isolated from the Indian subcontinent, solvent-based extracts were prepared using methanol:chloroform (S1, v/v) and ethyl acetate (S2). The DPPH and ABTS radical scavenging assays revealed maximum inhibition (65.42% and 69.73%) by S1 extract of Cylindrotheca sp. (D3) and 72.08% and 77.43% by S2 extracts of Chaetoceros sp. (D1), respectively. Both S1 and S2 extract of Cylindrotheca sp. showed maximum zone of inhibition (24 ± 0.4 mm) against Aeromonas sp. and Streptococcus pneumoniae. Further, in-vitro anticancer assessment was also done against renal adenocarcinoma (ACHN), lung carcinoma (A549), and ovarian carcinoma (SK-OV3) cell lines. Highest cytotoxicity was observed when SK-OV3 (63.3%) and A549 (53.6% ) cells were treated with 250 µg mL

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsAntioxidantsDiatomsAeromonasCell Line, TumorHumansMicroalgaeMicrobial Sensitivity TestsStreptococcus pneumoniaeAnti-Bacterial AgentsAntineoplastic AgentsAntioxidantsAntibacterialAntioxidantBioactive lipidsCytotoxicityDiatomsMetabolite profile

Identifiers

PMID40287447
PMCPMC12033239

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.