ArticleNPJ Parkinson's disease2025
Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Driving motor cortex oscillations restores plasticity and improves bradykinesia features in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Spatial propagation of movement-related basal ganglia activity predicts parkinsonian motor state.Brain : a journal of neurology · 2026Article
- Simultaneous MEG-LFP Recordings to Assess In Vivo Dystonic Neurophysiological Networks: A Feasibility Study.Brain sciences · 2025Article
- Beta bursts spatiotemporal profiles and their links to hemodynamic responses during movement and rest.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Compound network dynamics in beta and gamma bands determine the severity of bradykinesia in Parkinson's disease. We explored its subthalamic stimulation related changes parallel with improvement of complex hand movements. Thirty eight patients with Parkinson's disease treated with bilateral stimulation accomplished voluntary and traced spiral drawing with their more affected hand on a digital tablet. A 64 channel electroencephalography was recorded, low and high beta and gamma power was computed in subthalamic and motor cortical sources at four stimulation levels. Subthalamic cortical effective connectivity was calculated, and subnetwork models were created. Beta power decreased, and gamma power increased in sources ipsilateral to stimulation with increasing stimulation intensity. Networks comprising the primary motor cortex played a dominant role in predicting the improvement of voluntary drawing speed. Subthalamic stimulation diminished the hyperdirect high beta information processing and promoted the cortico cortical interactions of the primary motor cortex in the high gamma band.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.