ArticleBritish journal of anaesthesia2025
A probabilistic model of behavioural emergence from general anaesthesia in mice.
Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Dynamic Electrocortical States and Paradoxical Complexity during Desflurane Anesthesia.Anesthesiology · 2026Article
- Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice.British journal of anaesthesia · 2026Article
- Early reactivation of medial temporal lobe neurons during emergence from propofol anesthesia in neurosurgical patients.bioRxiv : the preprint server for biology · 2026Article
- Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice.bioRxiv : the preprint server for biology · 2026Article
- Dynamic electrocortical states and paradoxical complexity during desflurane anesthesia.bioRxiv : the preprint server for biology · 2025Article
- Reanimation of rodents: an animal model for cognitive recovery from anaesthesia.British journal of anaesthesia · 2025Article
- Emergence from general anaesthesia: stochastic or deterministic?British journal of anaesthesia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundTime to emergence from general anaesthesia is highly variable between individuals. This variability has been attributed to individual differences in anaesthetic sensitivity. However, this hypothesis has not been verified experimentally. We explicitly test this hypothesis by quantifying emergence from anaesthesia repeatedly in the same individuals over time.
methodsGenetically identical adult (12-24 weeks old) male (n=40) and female (n=20) C57BL/6J mice were exposed to 2 h of isoflurane (0.90 vol%) on 10 separate occasions. Time to emergence was measured using the return of the righting reflex. Predictions of the standard effect-site pharmacokinetic-pharmacodynamic (PK-PD) model and neuronal dynamics model of stochastic fluctuations between the awake and anaesthetised states were fit to observed emergence times. Repeated steady-state assessments of the righting reflex obtained during the last 2 h of a 4-h exposure to 0.3, 0.4, 0.6, or 0.7 vol% isoflurane (n=20 per concentration) were used to determine individual probabilities of losing the righting reflex, which was defined as an individual's anaesthetic sensitivity.
resultsEmergence times varied by at least two orders of magnitude after identical anaesthetic exposure. We did not find consistent inter-individual differences in emergence times. Instead, we found that variability in emergence times across trials in each individual was as large as that between two different individuals. Emergence times were not correlated across time. Consistent with previous work, we identified large individual differences in anaesthetic sensitivity which persisted on a time scale of at least 1 week. A standard PK-PD model failed to reproduce inter-trial variability. In contrast, the neuronal dynamics model reproduced both population- and individual-level variability in emergence times.
conclusionsStochastic state switching contributes to inherent variability in emergence from general anaesthesia. Delayed emergence occurred in a small proportion of anaesthetic exposures in a genetically homogeneous population. The neuronal dynamics model predicts that anaesthetic emergence times will be probabilistically long, which might explain delayed emergence observed in clinical settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.