Updates in the Understanding of Immunoglobulin Replacement Therapy in Primary Immune Deficiency Disorders: Function, Composition, and Role in Reconstitution and Immunomodulation.

Talal Mousallem, Geoffrey Hall, Alice Pan, Eveline Y Wu

Abstract readReview

In one paragraph

Review in Immunology and allergy clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Talal MousallemDivision of Allergy/Immunology, Department of Pediatrics, Duke University Medical Center, 133 MSRB, Box 2644, Durham, NC 27710, USA.

Geoffrey HallDivision of Allergy/Immunology, Department of Pediatrics, Duke University Medical Center, 133 MSRB, Box 2644, Durham, NC 27710, USA.

Alice PanDepartment of Pharmacy, UNC Health, 030 MacNider Hall, CB #7231, Chapel Hill, NC 27599, USA.

Eveline Y WuDivision of Pediatric Rheumatology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Pediatic Allergy/Immunology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: eywu@email.unc.edu.

Funding

Training of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2009 to 2023

$23.3M

RESEARCH TRAINING IN ALLERGY AND CLINICAL IMMUNOLOGYT32AI007062 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David B. Peden, John W. Sleasman · 1985 to 2026

$6.1M

NIAID NIH HHS T32 AI007062NIAID NIH HHS U54 AI082973

6 · The paper itself

Abstract

Clinical indications for immunoglobulin therapy can be broadly classified into replacement therapy for immunodeficiencies, immunomodulatory treatment of inflammatory conditions, and hyperimmune therapy against specific infectious agents. When starting immunoglobulin therapy, there are important considerations for the clinician including indication and function, composition, dosing, route, and safety. Immunoglobulin therapy should be tailored to an individual patient. This review discusses our current understanding and practical considerations for using immunoglobulin therapy for both humoral immune reconstitution and immunomodulation.

Indexed as

ImmunoglobulinsImmunoglobulins, IntravenousImmunologic Deficiency SyndromesImmunomodulationHumansImmunization, PassiveImmunoglobulinsImmunoglobulins, IntravenousImmunoglobulin replacement therapyImmunomodulationIntravenous immunoglobulinPrimary immunodeficienciesSubcutaneous immunoglobulin

Identifiers

PMID40287171

DOI10.1016/j.iac.2025.01.007

PMCPMC13507981

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.