ArticleJournal of affective disorders2025
White matter hyperintensities and relapse risk in late-life depression.
Article in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Longitudinal Changes in White Matter Hypointensities in Recurrent Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The global burden of depression in adolescents and young adults, 1990-2021: systematic analysis of the global burden of disease study.BMC psychiatry · 2025Article
- Vascular risk factors and neuroimaging heterogeneity across different white matter hyperintensities distribution patterns.Frontiers in human neuroscience · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundWhite matter hyperintensities (WMHs) are associated with late-life depression (LLD) and are considered a hallmark of MRI-defined vascular depression. However, their impact on depression recurrence in LLD is less well known.
methodsWe investigated this relationship using data from a 2-year multi-site, longitudinal study, where baseline WMH volumes were obtained using 3 T FLAIR magnetic resonance imaging (MRI) from 145 participants, of which 102 had remitted LLD and 43 were control participants. We analyzed the effect of baseline WMH volume on LLD relapse over 2 years using regression and adjusting for total intracranial volume, age, sex, race, education, and study site. We performed survival analyses using a Cox proportional hazard model to determine whether baseline WMH volume was associated with time to relapse in LLD.
resultsWe found that participants with LLD had greater WMH volume at baseline than control participants, but not if accounting for peripheral cardiovascular disease. Participants with LLD who relapsed within 8 months of baseline had larger WMH volume than control participants but did not statistically differ from those that remained remitted; this effect was lost when expanding to participants that relapsed at any point in the 2-year study. WMH burden was not associated with time to relapse, suggesting greater WMH volumes are not indicative of faster relapse rates in LLD.
conclusionOur results show that WMH burden may play a role in the early - but not the delayed - relapse of LLD, and they underscore the intricate dynamic of the biological markers underlying LLD treatment response and relapse.
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