Trial reportJournal of affective disorders2025
Affective theory of mind impairments linked with callous-unemotional traits implicate cognitive control: A pre-registered double-blind randomized controlled trial with a dual-task paradigm.
Trial report in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Probabilistic Cognitive State Modeling (PCSM): Decoding dynamic brain states to derive emergent cognitive processing properties from task fMRI.NeuroImage · 2026Article
- Probabilistic Cognitive State Modeling (PCSM): Decoding Latent Spatiotemporal Dynamics to Reveal Serial-Parallel Processing, Cognitive Demand, and Serial Bottleneck in Task-Based fMRI.bioRxiv : the preprint server for biology · 2025Article
- Cognitive Control Difficulties Differentiate Callous-Unemotional Traits from Conduct Problems: A Pre-Registered Double-Blind Randomized Controlled Trial Analysis.Child psychiatry and human development · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionYouth antisocial behavior strongly associates with conduct problems (CP) and callous-unemotional (CU) traits. While CP has links to broad cognitive impairments, CU traits have specific links with cognitive control and affective theory of mind (ToM) difficulties. Evidence suggests cognitive control limitations impact affective processing in ToM amongst youth with elevated CU traits. Here we sought to improve on those initial findings by leveraging a randomized dual-task (within-trial) design to replicate and extend prior findings.
methodsIn this double-blind, randomized controlled trial, 85 participants (47 % female) were stratified by sex and CU trait severity. The study employed a ToM task with cognitive, affective, and physical conditions, combined with an inhibitory processing task to tax cognitive control. Participants completed single and dual-task trials, counterbalanced to test within-subject effects. Primary hypotheses were tested with both CP and CU traits in the same model using repeated measure mixed effects to examine changes in accuracy and reaction time.
resultsCU traits were uniquely associated with greater impairments in affective ToM under dual-task conditions, reflecting increased difficulty integrating affective information when cognitive demands were increased. CP associated with lower single ToM performance but no change during dual-task trials. Notably, participants resilient to dual-task effects reported fewer antisocial behaviors, even with elevated CU traits. LIMITATIONS: While appropriately powered for study aims, the sample was underpowered to detect any potential primary and secondary variant interactions on study outcomes.
conclusionsThese findings support a CU trait specific cognitive-affective interaction as a mechanism critical for understanding youth antisocial behavior.
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