ArticleJournal of thrombosis and haemostasis : JTH2025
Pathways regulating the levels of tissue factor-positive extracellular vesicles and activation of coagulation in endotoxemic mice.
Article in Journal of thrombosis and haemostasis : JTH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Tissue factor detection in mouse tissues by western blotting using commercial antibodies.Research and practice in thrombosis and haemostasis · 2026Article
- Toward targeting of inflammasome signaling in venous thrombosis.Journal of thrombosis and haemostasis : JTH · 2025Review
- Disrupting the TRAF1/cIAP2 interaction attenuates inflammasome activation and protects against monosodium urate crystal-induced arthritis.ImmunoHorizons · 2025Article
- Role of monocytes in the pathogenesis of antiphospholipid syndrome and potential therapeutic targets (Review).Molecular medicine reports · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundSepsis and endotoxemia are associated with activation of coagulation as part of the host response to infection, but this can lead to disseminated intravascular coagulation. Lipopolysaccharide (LPS) is detected by the cell surface receptor toll-like receptor (TLR)4 and the intracellular receptor caspase 11.
objectivesThis study aimed to determine the roles of TLR4, caspase 11, and the NOD-, LRR-, and pyrin domain-containing protein (NLRP)3 inflammasome in increases of extracellular vesicle (EV) tissue factor (TF) activity and activation of coagulation in a mouse endotoxemia model.
methodsLPS was injected intraperitoneally into control mice and Tlr4
resultsLPS induced IL-1β at 3 and 8 hours, indicating inflammasome activation at these times. Tlr4 deficiency was associated with a significant decrease in tumor necrosis factor α and IL-6 but not soluble intercellular adhesion molecule 1 in endotoxemic mice. LPS induction of EV TF activity and TAT reduced significantly in Tlr4
conclusionOur results indicate that TLR4 plays a major role whereas caspase 11 and the NLRP3 inflammasome play minor roles in the generation of TF-positive EVs and activation of coagulation in a mouse model of endotoxemia.
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