Evidence map›Paper›PMID 40286863›Full record

ArticleExperimental neurology2025

Hypercholesterolemia drives microglial dysfunction and weakens response to amyloid plaques.

Sarah Kaye, Andrew Gold, Da Lin, Min Chen, Jiangjiang Zhu, Jie Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah KayeDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Andrew GoldDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Da LinDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Min ChenDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Jiangjiang ZhuDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Jie GaoDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: Jie.Gao@osumc.edu.

Funding

Targeting IDOL-ApoE receptor pathway in Alzheimer's diseaseR01AG073310 · NIA · OHIO STATE UNIVERSITY · PI Jie Gao · 2022 to 2026
$2.7M
Targeting IDOL-ApoE receptor pathway in Alzheimer's diseaseR56AG073310 · NIA · OHIO STATE UNIVERSITY · PI GAO, JIE · 2021 to 2021
$394k
NIA NIH HHS R01 AG073310NIA NIH HHS R56 AG073310
6 · The paper itself

Abstract

Hypercholesterolemia is a recognized comorbidity of Alzheimer's disease (AD), yet its mechanistic connection to AD pathology, particularly its impact on microglial function and amyloid-beta (Aβ) dynamics remains unclear. To investigate this, we utilized the APP

Indexed as

Alzheimer DiseaseHypercholesterolemiaMicrogliaPlaque, AmyloidAnimalsDiet, WesternDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, LDLReceptors, LDLAlzheimer's diseaseAmyloid betaHypercholesterolemiaMicroglia

Identifiers

PMID40286863
PMCPMC13109962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.