ArticleEcotoxicology and environmental safety2025
Cumulative environmental exposures and metabolic syndrome: A study of heavy metals and volatile organic compounds.
Article in Ecotoxicology and environmental safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The associations between volatile organic compounds and bone loss around teeth among US adults.BMC public health · 2026Article
- Article
- Exploring the Impact of E‑Waste Exposure on Childhood Blood Pressure: Metabolomics Analysis and Risk Prediction.Environment & health (Washington, D.C.) · 2026Article
- Integrated metabolomics reveals lipid mediators and food-associated chemicals associated with metabolic syndrome.Frontiers in nutrition · 2026Article
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12 authors.
Funding
Abstract
backgroundMetabolic Syndrome (MetS), a condition affecting over one-third of the U.S. population, heightens the risk of cardiovascular disease, Type 2 diabetes, and premature mortality. While individual links between heavy metals (HM), volatile organic compounds (VOC), and MetS have been established, the impact when these environmental toxins are combined remains unclear and unexplored. This study investigates how simultaneous exposure to HMs and VOCs influences the risk of MetS.
methodsWeighted Quantile Sum regression and Bayesian kernel Machine Regression were performed on data from 6603 participants in the National Health and Nutrition Examination Survey (2011-2020) to determine the impact of HMs and VOCs detected in urine on MetS. Further analyses were performed for individuals placed in subgroups based on age, sex, race/ethnicity, and monthly poverty level index.
resultsThe analyses reveal that combined exposure to HMs and VOCs is associated with an increased risk of MetS; in particular, exposure to cadmium, tin, N-acetyl-S-(N-methyl carbamoyl)-L-cysteine, and N-acetyl-S-(2-carboxyethyl)-L-cysteine significantly elevates the risk of developing MetS. Younger adults (18-50 years), men, Hispanics and non-Hispanic whites, and those with a monthly poverty index > 1.3 (higher socioeconomic status) emerged as the most vulnerable groups.
conclusionThese findings emphasize an urgent need to address and tackle the cumulative impact of environmental toxins through a shift in public health efforts to go beyond investigating isolated exposures to address real-world chemical exposures. By understanding these cumulative risks, we can begin to mitigate them and pave the way for more effective interventions, especially for at-risk populations.
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