Evidence map›Paper›PMID 40286506›Full record

ArticleInfant behavior & development2025

Social communication skills profile in infants with sex chromosome trisomy at 12 months of age.

Rebecca Wilson, Samantha Bothwell, Stephanie K Takamatsu, Talia Thompson, Karli Swenson, Emily Werner, Nicole Tartaglia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infant behavior & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca WilsonDepartment of Pediatrics, University of Colorado School of Medicine, USA; Extraordinary Kids Clinic, Developmental Pediatrics, Children's Hospital Colorado, USA.
Samantha BothwellDepartment of Pediatrics, University of Colorado School of Medicine, USA; Extraordinary Kids Clinic, Developmental Pediatrics, Children's Hospital Colorado, USA.
Stephanie K TakamatsuDepartment of Pediatrics, University of Colorado School of Medicine, USA; Extraordinary Kids Clinic, Developmental Pediatrics, Children's Hospital Colorado, USA.
Talia ThompsonDepartment of Pediatrics, University of Colorado School of Medicine, USA; Extraordinary Kids Clinic, Developmental Pediatrics, Children's Hospital Colorado, USA.
Karli SwensonDepartment of Pediatrics, University of Colorado School of Medicine, USA; Extraordinary Kids Clinic, Developmental Pediatrics, Children's Hospital Colorado, USA.
Emily WernerDepartment of Pediatrics, University of Colorado School of Medicine, USA.
Nicole TartagliaDepartment of Pediatrics, University of Colorado School of Medicine, USA; Extraordinary Kids Clinic, Developmental Pediatrics, Children's Hospital Colorado, USA. Electronic address: Nicole.Tartaglia@ChildrensColorado.org.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
The eXtraordinarY Babies Study: Natural History of Health and Neurodevelopment in Infants with Sex Chromosome TrisomyR01HD091251 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Nicole Renee Tartaglia · 2017 to 2026
$5.6M
NCATS NIH HHS UL1 TR002535NCATS NIH HHS UM1 TR004399NICHD NIH HHS R01 HD091251
6 · The paper itself

Abstract

Sex Chromosome Trisomy (SCT) conditions are genetic disorders that affect approximately 1:500 children. Although there is considerable variability in phenotype, individuals with SCT have an elevated likelihood, compared to the general population, of developing social deficits and autism spectrum disorder (ASD). Studies report that 10-35 % of individuals with SCT meet criteria for ASD, depending on differences in ascertainment methods and diagnostic criteria. More specifically, ASD prevalence has been estimated at approximately 18 % (range 10-27 %) for XXY, 15 % (10.8-20 %) for XXX, and 30 % (19-43 %) for XYY.

Indexed as

Autism Spectrum DisorderKlinefelter SyndromeSocial SkillsTrisomyFemaleHumansInfantMaleXYY KaryotypeSex chromosome trisomySocial communicationXXY, Klinefelter syndromeXYY, XXX, Trisomy X

Identifiers

PMID40286506
PMCPMC12448263

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.