Trial reportThe Journal of urology2025
Acoustic Enhancer Microbubble Cavitation: A Randomized Clinical Trial Evaluating the Safety and Efficacy of a Novel Treatment for Urolithiasis.
Trial report in The Journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe efficacy of ureteroscopy to treat urinary stones is often less than 60%. Acoustic Enhancer is an investigational device of microparticles with a tag designed with an affinity for calcium. We evaluated safety and efficacy of ureteroscopic laser lithotripsy with and without Acoustic Enhancer Microbubble Cavitation in a randomized clinical trial. MATERIALS AND
methodsPatients with urolithiasis were randomized to ureteroscopic laser lithotripsy with or without Acoustic Enhancer. The end points were the proportion of patients without residual fragments ≥ 2 mm on CT 30 days post procedure (fragment-free rate) and adverse events (AEs).
resultsThere were 103 and 93 patients in the investigational and control groups, respectively. There was no statistical superiority between the 2 groups. The fragment-free rate was 41% and 47% in the investigational and control groups, respectively (
conclusionsAlthough laser lithotripsy with microbubble cavitation did not increase efficacy, it was associated with significantly fewer AEs. Efficacy of microbubble cavitation may depend on laser power used. The low efficacy and high rates of AEs with ureteroscopy highlight the need for novel management approaches for urinary stones.
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