ArticleChemistry & biodiversity2025
New Terpenoids from Viguiera dentata: In Silico Pesticide-Likeness Properties, Acetylcholinesterase Inhibition, Molecular Docking, and Evaluation against Spodoptera frugiperda.
Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The chemical analysis of the melliferous plant Viguiera dentata (Asteraceae) yielded cycloartanes 1-9 (including the new compounds 7-9), ent-kaurenes (10-15), diversifolin (16) and other constituents. The structure of 9 was confirmed by X-ray analysis. To evaluate the insecticidal potential of its constituents, in silico pesticide-likeness calculations for structures 1-16 were performed indicating no violations of the Tice rules. Tests for activity against acetylcholinesterase revealed that only cycloartanes 1 (78.85 µM) and 6 (53.54 µM) inhibited the enzyme. Molecular docking analysis showed interactions between compounds 1, 10, and 13, with Y337, a key amino acid in the catalytic site. A bioassay against Spodoptera frugiperda revealed that compounds 1, 2, 9, 10, and 13 displayed activity (50% lethal concentration for larval mortality [LC
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