ArticleIET systems biology
Identification of HIBCH and MGME1 as Mitochondrial Dynamics-Related Biomarkers in Alzheimer's Disease Via Integrated Bioinformatics Analysis.
Article in IET systems biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review.Molecular neurobiology · 2026Pooled it
- Network Pharmacology Combined With Metabonomics and Transcriptomics Reveals the Mechanism ofFood science & nutrition · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Mitochondrial dynamics (MD) play a crucial role in the genesis of Alzheimer's disease (AD); however, the molecular mechanisms underlying MD dysregulation in AD remain unclear. This study aimed to identify critical molecules of MD that contribute to AD progression using GEO data and bioinformatics approaches. The GSE63061 dataset comparing AD patients with healthy controls was analysed, WGCNA was employed to identify co-expression modules and differentially expressed genes (DEGs) and LASSO model was developed and verified using the DEGs to screen for potential biomarkers. A PPI network was built to predict upstream miRNAs, which were experimentally validated using luciferase reporter assays. A total of 3518 DEGs were identified (2209 upregulated, 1309 downregulated; |log
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.