Evidence map›Paper›PMID 40286321›Full record

ReviewClinical and translational science2025

Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates.

Julia K Sundheimer, Julia Benzel, Rémi Longuespée, Jürgen Burhenne, Stefan M Pfister, Kendra K Maaß, Max Sauter, Kristian W Pajtler

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia K SundheimerHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.ORCID 0009-0005-9296-8098
Julia BenzelHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Rémi LonguespéeMedical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-2003-1886
Jürgen BurhenneMedical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-2190-1698
Stefan M PfisterHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.ORCID 0000-0002-5447-5322
Kendra K MaaßHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.ORCID 0000-0001-9357-5038
Max SauterMedical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-4977-1925
Kristian W PajtlerHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.ORCID 0000-0002-3562-6121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral microdialysis in rodents represents a robust and versatile technique for quantifying the pharmacologically relevant unbound fraction of drugs in the brain. When this unbound fraction is simultaneously determined in plasma, it facilitates the calculation of the corresponding unbound plasma-to-brain partition coefficient (K

Indexed as

BrainMicrodialysisAnimalsBlood-Brain BarrierHumansHydrophobic and Hydrophilic InteractionsMiceRatsReproducibility of Resultscentral nervous systemcerebral microdialysischemical drug propertiesnon‐specific bindingprobe implantation

Identifiers

PMID40286321
PMCPMC12033007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.