Evidence map›Paper›PMID 40286270›Full record

ArticleCell reports2025

Mitochondrial Ca

Jillian S Weissenrieder, Jessica Peura, Usha Paudel, Nikita Bhalerao, Natalie Weinmann, Calvin Johnson, Maximilian Wengyn, Rebecca Drager, Emma Elizabeth Furth, Karl Simin and 5 more

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  9. Mitochondrial metabolism and cancer therapeutic innovation.Signal transduction and targeted therapy · 2025
    Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Jillian S WeissenriederDepartment of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jessica PeuraDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Usha PaudelDepartment of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Nikita BhaleraoDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Natalie WeinmannDepartment of Chemistry, Millersville University, Millersville, PA, USA.
Calvin JohnsonDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Maximilian WengynDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-5157, USA.
Rebecca DragerDepartment of Chemistry, The Ohio State University, Columbus, OH, USA.
Emma Elizabeth FurthDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Karl SiminDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Marcus RuscettiDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Ben Z StangerDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-5157, USA.
Anil K RustgiHerbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York City, NY 10032, USA.
Jason R PitarresiDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: jason.pitarresi@umassmed.edu.
J Kevin FoskettDepartment of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: foskett@pennmedicine.upenn.edu.

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5M
Electrophysiology of nuclear membrane InsP3 receptorR37GM056328 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN · 2011 to 2020
$4.9M
Endoplasmic Reticulum-to-Mitochondria Calcium Transfer in Pancreatic Cancer Development, Metastasis, and TreatmentR01CA250173 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN · 2021 to 2025
$2.6M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
IMSD at the University of Massachusetts Medical SchoolT32GM135751 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRIAN C LEWIS, Kate L Lapane · 2020 to 2026
$2.2M
Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancerR00CA252153 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PITARRESI, JASON R. · 2022 to 2024
$747k
The Mitochondrial Calcium Uniporter in Pancreatic Cancer Development, Metastasis, and TreatmentF32CA250144 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WEISSENRIEDER, JILLIAN · 2021 to 2023
$205k
NCI NIH HHS F32 CA250144NCI NIH HHS R00 CA252153NCI NIH HHS R01 CA250173NIAID NIH HHS T32 AI095213NIDDK NIH HHS P30 DK050306NIGMS NIH HHS R37 GM056328NIGMS NIH HHS T32 GM135751
6 · The paper itself

Abstract

Endoplasmic reticulum to mitochondria Ca

Indexed as

CalciumCarcinoma, Pancreatic DuctalCell PlasticityEpithelial CellsMitochondriaPancreatic NeoplasmsAnimalsCalcium ChannelsCell Line, TumorCell ProliferationEpithelial-Mesenchymal TransitionHumansMiceNeoplasm MetastasisSnail Family Transcription FactorsTransforming Growth Factor betaCalciumCalcium Channelsmitochondrial calcium uniporterSnail Family Transcription FactorsTransforming Growth Factor betacalcium signalingcancerCP: CancerCP: MetabolismEMTepithelial-to-mesenchymal transitionMCUmetabolismmitochondriapancreasPDACuniporter

Identifiers

PMID40286270
PMCPMC12857258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.