Evidence map›Paper›PMID 40286223›Full record

ArticleMolecules (Basel, Switzerland)2025

Anti-Cancer Stem Cell Properties of Square Planar Copper(II) Complexes with Vanillin Schiff Base Ligands.

Yihan Wang, Kuldip Singh, Chunxin Lu, Kogularamanan Suntharalingam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yihan WangSchool of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
Kuldip SinghSchool of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
Chunxin LuCollege of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China.
Kogularamanan SuntharalingamSchool of Chemistry, University of Leicester, Leicester LE1 7RH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current breast cancer therapies are unable to positively impact the lives of a significant proportion of diagnosed patients (24% based on 10-year survival rate). Breast cancer relapse and metastasis, the leading cause of breast cancer-associated deaths, is linked to the existence of breast cancer stem cells (CSCs). Redox-modulating metal complexes have been used to perturb the redox balance in breast CSCs and effect cell death. Here, we sought to expand this promising class of anti-breast CSC agents. Specifically, we report the synthesis, and anti-breast CSC properties of a series of copper(II) complexes bearing regioisomeric vanillin Schiff base ligands (

Indexed as

Antineoplastic AgentsBenzaldehydesCoordination ComplexesCopperNeoplastic Stem CellsApoptosisBreast NeoplasmsCell Line, TumorCrystallography, X-RayFemaleHumansLigandsReactive Oxygen SpeciesSchiff BasesAntineoplastic AgentsBenzaldehydesCoordination ComplexesCopperLigandsReactive Oxygen SpeciesSchiff Basesvanillinbioinorganic chemistrycancer stem cellscoppermetallopharmaceuticalsreactive oxygen species

Identifiers

PMID40286223
PMCPMC11990672

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.