Evidence map›Paper›PMID 40286222›Full record

ReviewMolecules (Basel, Switzerland)2025

The Occurrence, Uses, Biosynthetic Pathway, and Biotechnological Production of Plumbagin, a Potent Antitumor Naphthoquinone.

Polavarapu B Kavi Kishor, Bangaru Naidu Thaddi, Rajasheker Guddimalli, Tukaram Dayaram Nikam, Krothapalli Raja Surya Sambasiva Rao, Rupasree Mukhopadhyay, Prashant Singam

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Polavarapu B Kavi KishorDepartment of Genetics, Osmania University, Hyderabad 500007, India.ORCID 0000-0002-9587-7547
Bangaru Naidu ThaddiDepartment of Life Sciences, Aditya Degree & P.G. College (Autonomous), Kakinada 533003, India.
Rajasheker GuddimalliDepartment of Genetics, Osmania University, Hyderabad 500007, India.ORCID 0000-0002-0191-9639
Tukaram Dayaram NikamDepartment of Botany, Savitribai Phule Pune University, Pune 411007, India.ORCID 0000-0002-0236-1489
Krothapalli Raja Surya Sambasiva RaoDepartment of Pharmacy, Mangalayatan University-Jabalpur, Jabalpur 483001, India.
Rupasree MukhopadhyayDepartment of Genetics & Biotechnology, Veeranari Chakali Ilamma Women's University, Hyderabad 500095, India.
Prashant SingamDepartment of Genetics, Osmania University, Hyderabad 500007, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plumbagin is an important naphthoquinone with potent anticancer properties besides multitudinous uses in healthcare. It is produced in a limited number of species and families but mostly in the roots of Plumbaginaceae family members. The biosynthetic pathway and the genes that regulate plumbagin synthesis are not completely known, but details of these are being revealed. Several species, including

Indexed as

Antineoplastic Agents, PhytogenicBiosynthetic PathwaysBiotechnologyNaphthoquinonesPlumbaginaceaeHumansPlant RootsAntineoplastic Agents, PhytogenicNaphthoquinonesplumbaginanticancer compoundbioreactorscell cultureshairy rootsplumbagin

Identifiers

PMID40286222
PMCPMC11990497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.