ArticlePrenatal diagnosis2025
Prenatal Predictors of Early Intervention in Simple Tetralogy of Fallot: A Retrospective Multi-Centre Study.
Article in Prenatal diagnosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Survival and Associated Factors for Mortality Among Infants with Tetralogy of Fallot in a Middle-Income Country.Pediatric cardiology · 2026Article
- Prognostic value of fetal growth and prenatal functional echocardiography in tetralogy of FALLOT.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Clinical Value of Serum APOC1, LMNA, and TPM4 in Predicting Fetal Cardiac Abnormalities in Elderly Parturients.International journal of women's health · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivePrenatal predictors of early postnatal intervention in tetralogy of Fallot (ToF) remain uncertain. This study aimed to identify prenatal cardiac and non-cardiac predictors of disease severity associated with early intervention in ToF.
methodsThis retrospective cohort study included prenatally diagnosed infants with simple ToF who underwent cardiac surgery or catheter intervention in their first year in Aotearoa New Zealand and Australia 2010-2019. Fetal echocardiography measurements from 28 to 32 weeks of gestation and prenatally diagnosed genetic and extracardiac structural anomalies were recorded. Comparison was made between infants undergoing early (≤ 30 days) and later intervention.
resultsOf 253 infants, 33 (13%) underwent an early intervention. Infants requiring early intervention had lower pulmonary valve (PV) Z-scores (-4.7 ± 2.2 vs. -2.6 ± 1.6; p < 0.0001) or abnormal ductus arteriosus (DA) flow (14/30 (47%) versus 20/158 (13%), p < 0.001). A PV Z-score ≤ -3.5 or abnormal flow in the DA strongly predicted the timing of intervention (sensitivity 79%, specificity 70%, AUC 0.81). There was no association between the presence of a genetic or extracardiac anomaly and the timing of cardiac intervention.
conclusionEarly intervention in ToF can be predicted from fetal echocardiogram measurements, including a PV Z-score ≤ -3.5 or abnormal DA flow at 28-32 weeks gestation. These findings have implications for prenatal counselling and planning of prenatal obstetric care.
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