ArticleMolecules (Basel, Switzerland)2025
Synthesis and Evaluation of the Antiproliferative Activity of the Derivatives of 3,5-Diaryl-3,4-dihydro-2
Vesela Mihaylova, Ivan Iliev, Anelia Vasileva, Elizabeth Mazzio, Bereket Mochona, Nelly Mateeva, Donka Tasheva
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Vesela MihaylovaDepartment of Organic Chemistry and Pharmacognosy, Faculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", 1 J. Bourchier Blvd., 1164 Sofia, Bulgaria.
Ivan IlievInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0002-2480-5116 Anelia VasilevaDepartment of Medical Chemistry and Biochemistry, Medical University of Sofia, 2, Zdrave Str., 1431 Sofia, Bulgaria.ORCID 0000-0002-5363-5611 Elizabeth MazzioCollege of Pharmacy and Pharmaceutical Science, Florida A&M University, 1415 South M.L. King, Jr. Blvd., Tallahassee, FL 32307, USA.
Bereket MochonaDepartment of Chemistry, Florida A&M University, 1530 South M.L. King, Jr. Blvd., Tallahassee, FL 32307, USA.ORCID 0000-0002-4359-6823 Nelly MateevaDepartment of Chemistry, Florida A&M University, 1530 South M.L. King, Jr. Blvd., Tallahassee, FL 32307, USA.
Donka TashevaDepartment of Organic Chemistry and Pharmacognosy, Faculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", 1 J. Bourchier Blvd., 1164 Sofia, Bulgaria.ORCID 0000-0003-3195-7684 Funding
Tissue Modeling & Drug Development Shared Resources CoreU54CA233444 · NCI · UNIVERSITY OF FLORIDA · PI Chanita A. Hughes-Halbert, Tianze Jiao · 2018 to 2026
$12.1MTissue Modeling CoreU54CA233465 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JOYCE M RICHEY · 2018 to 2026
$11.9MTissue Modeling CoreU54CA233396 · NCI · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI Romonia Renee REAMS · 2018 to 2026
$9.8MNational Institutes of Health (NIH), and National Cancer Institute (NCI) U54CA233396, U54CA233444, & U54CA233465NCI NIH HHS U54 CA233396NCI NIH HHS U54 CA233444NCI NIH HHS U54 CA233465
6 · The paper itselfAbstract
The metabolic cycle of L-proline plays a crucial role in cancer cell survival, proliferation, and metastasis. A key intermediate in the biosynthesis and degradation of proline is 3,4-dihydro-2
Indexed as
Antineoplastic AgentsCarboxylic AcidsPyrrolesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsCarboxylic AcidsPyrroles3,4-dihydro-2H-pyrrole-2-carbonitrilesantiproliferative activityhydrolytic cyclizationin vitro screeningMichael additionselectivity index
Identifiers
PMID40286188
PMCPMC11990662
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