Evidence map›Paper›PMID 40286177›Full record

ArticleMolecules (Basel, Switzerland)2025

Insights into the Antimicrobial Mechanisms of a Scorpion Defensin on

Xuhua Yang, Haozhen Zhang, Sijia Lu, Yiyuan Guo, Yitong Li, Chenhu Qin, Zheng Zuo, Yingliang Wu, Zhijian Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuhua YangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.
Haozhen ZhangCollege of Life Sciences, Wuhan University, Wuhan 430072, China.
Sijia LuCollege of Life Sciences, Wuhan University, Wuhan 430072, China.ORCID 0009-0008-3182-1430
Yiyuan GuoCollege of Life Sciences, Wuhan University, Wuhan 430072, China.ORCID 0009-0000-6988-1596
Yitong LiCollege of Life Sciences, Wuhan University, Wuhan 430072, China.
Chenhu QinDepartment of Biochemistry and Molecular Biology, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Zheng ZuoCollege of Life Sciences, Wuhan University, Wuhan 430072, China.
Yingliang WuCollege of Life Sciences, Wuhan University, Wuhan 430072, China.
Zhijian CaoNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.

Funding

Green Science and Technology Leading Program from Hubei University of Technology XJ2024000201Hubei University of Technology High-level Talent Launch Fund GCC2024009Joint Fund of National Natural Science Fund of China 32161160303National Key Research and Development Program of China 2023YFF1304900National Natural Science Foundation of China 32170519National Natural Science Foundation of China 32370547Science and Technology Development Fund of Macau SAR 0010/2021/AFJ
6 · The paper itself

Abstract

Defensins constitute a family of cationic antimicrobial peptides that act against different bacteria; however, global information regarding their antibacterial mechanisms from omics-based analyses is highly limited. In this study, transcriptomics and proteomics were used to explore the antibacterial mechanisms of defensin (BmKDfsin4) originally isolated from a scorpion on a common Gram-positive bacterium.

Indexed as

Anti-Bacterial AgentsDefensinsProteomicsScorpionsStaphylococcus aureusTranscriptomeAnimalsBacterial ProteinsGene Expression ProfilingGene Expression Regulation, BacterialAnti-Bacterial AgentsBacterial ProteinsDefensinsantibacterial mechanismbacteriumBmKDfsin4defensinproteomeStaphylococcus aureustranscriptome

Identifiers

PMID40286177
PMCPMC11990343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.