Evidence map›Paper›PMID 40286161›Full record

ArticleMolecules (Basel, Switzerland)2025

Anticancer Activity and Safety Profile of Novel 1-(4-Fluorophenoxyacetyl)-4-substituted Thio/Semicarbazide Derivatives.

Paweł Kozyra, Ewelina Humeniuk, Zbigniew Karczmarzyk, Adrian Borzęcki, Grzegorz Adamczuk, Agnieszka Korga-Plewko, Waldemar Wysocki, Monika Pitucha

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paweł KozyraIndependent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0001-8071-8503
Ewelina HumeniukIndependent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-4356-0828
Zbigniew KarczmarzykInstitute of Chemistry, University of Siedlce, 3 Maja 54, 08-110 Siedlce, Poland.
Adrian BorzęckiIndependent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.
Grzegorz AdamczukIndependent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-1677-7247
Agnieszka Korga-PlewkoIndependent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-2027-9681
Waldemar WysockiInstitute of Chemistry, University of Siedlce, 3 Maja 54, 08-110 Siedlce, Poland.ORCID 0000-0002-3205-114X
Monika PituchaIndependent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0001-8792-1029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compounds with thiosemicarbazide and semicarbazide scaffolds are among the most promising structures in medicinal chemistry due to the possibility of forming multiple hydrogen bonds. Therefore, six new derivatives of 4-fluorophenoxyacetylthiosemicarbazide and 4-fluorophenoxyacetylthiosemicarbazide were designed to compare their physicochemical properties, biological activity, and in silico pharmacokinetic parameters. All compounds were characterized by

Indexed as

Antineoplastic AgentsSemicarbazidesCell Line, TumorCell ProliferationHumansMaleMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsSemicarbazidesthiosemicarbazidecancerpharmacokineticsprooxidationsemicarbazidethiosemicarbazideX-ray

Identifiers

PMID40286161
PMCPMC11990103

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.