ArticleMolecules (Basel, Switzerland)2025
Synthesis and Antimicrobial Activity of Canthin-6-One Alkaloids.
Xubing Qi, Yogini Jaiswal, Xinrong Xie, Yu Fan, Rongping Wu, Shaoyang Su, Yifu Guan, Leonard Williams, Xun Song
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Xubing QiKey Laboratory of Chemistry and Engineering of Forest Products (State Ethnic Affairs Commission), Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Yogini JaiswalCenter for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, The North Carolina Research Campus, Kannapolis, NC 28081, USA.ORCID 0000-0002-3869-5288 Xinrong XieKey Laboratory of Chemistry and Engineering of Forest Products (State Ethnic Affairs Commission), Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Yu FanKey Laboratory of Chemistry and Engineering of Forest Products (State Ethnic Affairs Commission), Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Rongping WuKey Laboratory of Chemistry and Engineering of Forest Products (State Ethnic Affairs Commission), Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Shaoyang SuDepartment of Applied Chemistry Teaching and Research, Guangxi Vocational University of Agriculture, Nanning 530007, China.
Yifu GuanKey Laboratory of Chemistry and Engineering of Forest Products (State Ethnic Affairs Commission), Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Leonard WilliamsCenter for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, The North Carolina Research Campus, Kannapolis, NC 28081, USA.ORCID 0000-0003-0886-5204 Funding
National Natural Science Foundation of China 21967005Natural Science Foundation of Guangxi 2023GXNSFAA026340Research Start-up Foundation of Guangxi Minzu University 2019KJQD07
6 · The paper itselfAbstract
Canthin-6-one alkaloids have consistently attracted the interest of medicinal chemists due to their wide range of promising bioactivities, including antitumor, antifungal, antibacterial, and antiviral properties. However, their low natural abundance in plants has constrained the further exploration of their potential bioactivities. This study reports a comprehensive synthesis of canthin-6-one alkaloids, utilizing key Suzuki coupling and Cu-catalyzed amidation reactions to construct their core scaffold. Derivatives were synthesized with Koenig-Knorr glycosylation for the further modification of synthetic canthin-6-ones. The antimicrobial activities of the synthesized compounds were evaluated against
Indexed as
AlkaloidsAnti-Infective AgentsCarbolinesIndole AlkaloidsCandida albicansCryptococcus neoformansEscherichia coliHumansMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusAlkaloidsAnti-Infective Agentscanthin-6-oneCarbolinesIndole Alkaloidsantimicrobial activitycanthin-6-one alkaloidsderivativessynthesis
Identifiers
PMID40286147
PMCPMC11990583
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