Evidence map›Paper›PMID 40286130›Full record

ReviewMolecules (Basel, Switzerland)2025

The Co-Delivery of Natural Products and Small RNAs for Cancer Therapy: A Review.

Xuyi Wang, Shuang Li, Zelong Wang, Baorong Kang, Hong Yan

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuyi WangSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.ORCID 0009-0005-4633-705X
Shuang LiSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Zelong WangSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Baorong KangSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Hong YanSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.ORCID 0009-0001-7730-7962

Funding

Hunan Provincial Administration of Traditional Chinese Medicine Project A2024006Hunan Provincial Natural Science Foundation 2025JJ
6 · The paper itself

Abstract

This review summarizes the research progress in the co-delivery of natural products (NPs) and small RNAs in cancer therapy. NPs such as paclitaxel, camptothecin, and curcumin possess multi-target antitumor effects, but their applications are limited by drug resistance and non-specific distribution. Small RNAs can achieve precise antitumor effects through gene regulation, yet their delivery efficiency is low, and they are prone to degradation by nucleases. Nanomaterial-based drug delivery systems (nano-DDSs) provide an efficient platform for the co-delivery of both, which can enhance the targeting of their delivery and improve the synergistic antitumor effects simultaneously. The mechanisms of the antitumor action of natural compounds and small RNAs, the design and application of nanocarriers, and the latest research progress in co-delivery systems are introduced in detail in this paper. The application prospects of the co-delivery of natural compounds and small RNAs in cancer therapy are also discussed.

Indexed as

Antineoplastic AgentsBiological ProductsDrug Delivery SystemsNeoplasmsRNA, Small InterferingAnimalsHumansNanoparticlesAntineoplastic AgentsBiological ProductsRNA, Small Interferingcancerco-deliverygenenano-DDSnatural productsRNA

Identifiers

PMID40286130
PMCPMC11990496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.