Evidence map›Paper›PMID 40286104›Full record

ArticleMolecules (Basel, Switzerland)2025

DNA/BSA Binding Affinity and Cytotoxicity of Dinuclear Palladium(II) Complexes with Amino Acids as Ligands.

Stefan Jakovljevic, Petar Canovic, Marko Spasic, Marija Zivkovic, Milan Zaric, Radica Zivkovic Zaric, Andjela Franich, Snezana Rajkovic, Zeljko Todorovic, Nenad Relic and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stefan JakovljevicDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.
Petar CanovicDepartment of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.
Marko SpasicDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.ORCID 0000-0001-7144-1696
Marija ZivkovicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.ORCID 0000-0001-6887-9566
Milan ZaricDepartment of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.
Radica Zivkovic ZaricDepartment of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.
Andjela FranichDepartment of Chemistry, Faculty of Sciences, University of Kragujevac, Radoje Domanovic Street 12, 34000 Kragujevac, Serbia.
Snezana RajkovicDepartment of Chemistry, Faculty of Sciences, University of Kragujevac, Radoje Domanovic Street 12, 34000 Kragujevac, Serbia.ORCID 0000-0002-7135-4063
Zeljko TodorovicDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.ORCID 0000-0001-9989-5921
Nenad RelicDepartment of Otorhinolaryngology, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.ORCID 0000-0003-1066-476X
Milos ZivicDepartment of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.ORCID 0000-0002-9119-0692
Nikola MirkovicDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic Street 69, 34000 Kragujevac, Serbia.ORCID 0000-0003-1573-1191

Funding

Faculty of Medical Sciences, University of Kragujevac JP02/20Ministry of Science, Technological Development and Innovation Serbia 451-03-137/2025-03/200111; 451-03-136/2025-03/200111Serbian Academy of Sciences and Arts F128
6 · The paper itself

Abstract

This study investigates the synthesis, characterization, and cytotoxicity of dinuclear palladium(II) complexes with glycine (Pd1), alanine (Pd2), and methionine (Pd3) as ligands. UV-Vis and fluorescence spectroscopy were used to investigate the complexes' interactions with calf thymus DNA (CT-DNA) and bovine serum albumin. The obtained measurements demonstrate that Pd1 and Pd2 have stronger binding affinities for CT-DNA compared to Pd3, with Pd3 exhibiting the most significant cytotoxicity against the MDA-MB-231 cancer cell line. The binding behavior was quantified by calculating intrinsic binding constants (K

Indexed as

Amino AcidsAntineoplastic AgentsCoordination ComplexesDNAPalladiumSerum Albumin, BovineAnimalsApoptosisCattleCell Line, TumorHumansLigandsProtein BindingAmino AcidsAntineoplastic Agentscalf thymus DNACoordination ComplexesDNALigandsPalladiumSerum Albumin, Bovinealbuminamino acidsapoptosiscytotoxicityDNApalladiumpyrazine

Identifiers

PMID40286104
PMCPMC11990606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.