Evidence map›Paper›PMID 40286062›Full record

ArticleMolecules (Basel, Switzerland)2025

Determination and Disposition of the Aromatase Inhibitor Exemestane in CYP3A-Deficient Mice.

Hanieh Taheri, Eman Ahmed, Peng Hu, Alex Sparreboom, Shuiying Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanieh TaheriDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3236-7870
Eman AhmedDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Peng HuDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Alex SparreboomDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-2660-6644
Shuiying HuDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-9806-7734

Funding

The Chesapeake-Ohio Pharmacokinetics Core for The ETCTNU24CA247648 · NCI · JOHNS HOPKINS UNIVERSITY · PI Jan Hendrik Beumer, Mitch A Phelps · 2020 to 2026
$3.6M
Prevention of paclitaxel-induced peripheral neuropathy with nilotinibR01CA238946 · NCI · OHIO STATE UNIVERSITY · PI HU, SHUIYING, LUSTBERG, MARYAM B. · 2019 to 2023
$2.9M
Targeting neuronal transport to ameliorate vincristine neurotoxicityR01CA272254 · NCI · OHIO STATE UNIVERSITY · PI Sharyn D Baker, Shuiying Hu · 2023 to 2026
$2.6M
NCI NIH HHS R01 CA238946NCI NIH HHS R01 CA272254NCI NIH HHS U24 CA247648NIH HHS R01CA238946The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Pelotonia Foundation
6 · The paper itself

Abstract

Exemestane, a steroidal aromatase inhibitor prescribed for post-menopausal women with estrogen receptor-positive breast cancer, is associated with debilitating musculoskeletal side effects and exhibits considerable interindividual variability in systemic exposure. Although exemestane is metabolized mainly by cytochrome P-450 3A4, the contribution of this metabolic pathway to the elimination of exemestane and its drug-drug interaction liabilities remains uncertain. Here, we developed a novel quantification method for exemestane and applied it to evaluate the role of CYP3A-mediated metabolism in the pharmacokinetics of exemestane using wild-type and

Indexed as

AndrostadienesAromatase InhibitorsCytochrome P-450 CYP3AAnimalsChromatography, LiquidFemaleHumansMembrane ProteinsMiceMice, KnockoutAndrostadienesAromatase InhibitorsCyp3a11 protein, mouseCytochrome P-450 CYP3AexemestaneMembrane Proteinsaromatase inhibitorsexemestaneLC-MS/MSmouse plasmapharmacokinetics

Identifiers

PMID40286062
PMCPMC11990089

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.