Evidence map›Paper›PMID 40286027›Full record

ArticleMolecules (Basel, Switzerland)2025

Novel Isatin-Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation.

Rongrong Wang, Zhili Zhang, Wei Jiang, Junyi Liu, Chao Tian, Meng Wang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rongrong WangCollege of Pharmacy, Beihua University, Jilin 132013, China.
Zhili ZhangDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-2472-7234
Wei JiangCollege of Pharmacy, Beihua University, Jilin 132013, China.
Junyi LiuDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Chao TianDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Meng WangCollege of Pharmacy, Beihua University, Jilin 132013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is considered a significant factor in triggering numerous neurodegenerative diseases. Hence, the development of effective anti-inflammatory drugs is of utmost urgency. In this study, three series of new isatin-chalcone hybrid derivatives were successfully designed and synthesized, and their anti-neuritis activities were explored using BV2 microglial cells. The results indicated that compound

Indexed as

Anti-Inflammatory AgentsChalconeChalconesIsatinAnimalsCell LineDrug DesignInterleukin-6MiceMicrogliaMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipTumor Necrosis Factor-alphaAnti-Inflammatory AgentsChalconeChalconesInterleukin-6IsatinTumor Necrosis Factor-alphaanti-neuroinflammatoryIL-6isatinnitric oxideTNF-α

Identifiers

PMID40286027
PMCPMC11990898

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.