Evidence map›Paper›PMID 40286026›Full record

ArticleMolecules (Basel, Switzerland)2025

The Dynamical Asymmetry in SARS-CoV2 Protease Reveals the Exchange Between Catalytic Activity and Stability in Homodimers.

Velia Minicozzi, Alessandro Giuliani, Giampiero Mei, Leonardo Domenichelli, Mauro Parise, Almerinda Di Venere, Luisa Di Paola

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. 'Intelligent' proteins.Cellular and molecular life sciences : CMLS · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Velia MinicozziINFN and Department of Physics, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-9851-9932
Alessandro GiulianiDepartment of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-4640-804X
Giampiero MeiDepartment of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-3772-9463
Leonardo DomenichelliUnit of Chemical-Physics Fundamentals in Chemical Engineering, Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico of Rome, 00128 Rome, Italy.ORCID 0009-0006-9982-3788
Mauro PariseUnit of Electrotechnics, Department of Engineering, Università Campus Bio-Medico of Rome, 00128 Rome, Italy.ORCID 0000-0002-5479-7794
Almerinda Di VenereDepartment of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-9493-0270
Luisa Di PaolaUnit of Chemical-Physics Fundamentals in Chemical Engineering, Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico of Rome, 00128 Rome, Italy.ORCID 0000-0001-5329-8689

Funding

Ministero dell'università e della ricerca 2022PJKF88
6 · The paper itself

Abstract

The molecular approach to understanding the mechanisms of emerging diseases, like COVID-19, has largely accelerated the search for successful therapeutical strategies. In this work, we present an extensive molecular dynamics (MD) analysis of two forms of the SARS-CoV-2 main protease M

Indexed as

Coronavirus 3C ProteasesSARS-CoV-2Catalytic DomainCOVID-19HumansMolecular Dynamics SimulationProlineProtein MultimerizationCoronavirus 3C ProteasesN-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamideProlinedrug discoverymain protease (MPro)molecular dynamics (MD) simulationSARS-CoV-2structural analysistherapeutic interventions

Identifiers

PMID40286026
PMCPMC11990344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.