Evidence map›Paper›PMID 40286003›Full record

ReviewTopics in current chemistry (Cham)2025

Exploring the Synthetic Potential of Horner-Wadsworth-Emmons Reaction Toward the Synthesis of Polyketide Based Natural Products: A Review.

Javeria Babar, Sajjad Ahmad, Bushra Parveen, Kulsoom Ghulam Ali, Aqsa Mushtaq, Ameer Fawad Zahoor, Raheel Ahmad, Asim Mansha, Ahmad Irfan

Abstract readReview
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In one paragraph

Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Javeria BabarDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Sajjad AhmadDepartment of Chemistry, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad, 38000, Pakistan.
Bushra ParveenDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Kulsoom Ghulam AliDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Aqsa MushtaqDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Ameer Fawad ZahoorDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan. fawad.zahoor@gcuf.edu.pk.
Raheel AhmadDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Asim ManshaDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Ahmad IrfanDepartment of Chemistry, College of Science, King Khalid University, P.O. Box 9004, 61413, Abha, Saudi Arabia.

Funding

King Khalid University RGP2/151/45
6 · The paper itself

Abstract

The Horner-Wadsworth-Emmons (HWE) reaction is a commonly used and reliable phenomenon for carbon-carbon olefination in organic chemistry, carried out by treating aldehyde or ketones with phosphonate esters to afford the substituted alkenes. HWE reaction has also been observed to be involved in the stereo-controlled syntheses of naturally occurring compounds that acquire pharmaceutical profiles against various diseases. In this article, recent implementations of Horner-Wadsworth-Emmons reaction towards the notable total syntheses of naturally occurring compounds such as polyketides have been summarized.

Indexed as

Biological ProductsPolyketidesAlkenesKetonesMolecular StructureStereoisomerismAlkenesBiological ProductsKetonesPolyketidesMacrolidesNatural productsPolyketidesPolyphenols

Identifiers

PMID40286003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.