Evidence map›Paper›PMID 40285926›Full record

ArticleJournal of endocrinological investigation2025

Exposure profiles to Benzophenones and their impacts on thyroid hormones in pregnant women.

Khelfi Abderrezak, Askoufes Houyam, Alsayed Ahmad Dana, Afri Yamina, Talhi Randa, Henkel Ralf, Azzouz Mohamed

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khelfi AbderrezakUniversity of Algiers 1, 2 Didouche Mourad Street, 16000, Algiers, Algeria. khelfi_ar@hotmail.com.
Askoufes HouyamUniversity of Algiers 1, 2 Didouche Mourad Street, 16000, Algiers, Algeria.
Alsayed Ahmad DanaUniversity of Algiers 1, 2 Didouche Mourad Street, 16000, Algiers, Algeria.
Afri YaminaUniversity of Algiers 1, 2 Didouche Mourad Street, 16000, Algiers, Algeria.
Talhi RandaUniversity of Algiers 1, 2 Didouche Mourad Street, 16000, Algiers, Algeria.
Henkel RalfDepartment of Medical Bioscience, University of the Western Cape, Bellville, South Africa.
Azzouz MohamedUniversity of Algiers 1, 2 Didouche Mourad Street, 16000, Algiers, Algeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBenzophenones are ubiquitous compounds widely used in various industrial and consumer products including sunscreens, plastics, and personal care items. Their presence as emerging pollutants has raised concerns due to their potential adverse health effects, particularly as endocrine disrupting chemicals (EDCs). The aim of this study was to identify exposure profiles to Benzophenones in pregnant women living in Algiers and to explore associations between urinary levels of these compounds and disruptions of thyroid hormones levels during pregnancy.

methodsThis study was carried out on 384 pregnant women. After gathering necessary information using a questionnaire, blood and urine samples were collected. Thyroid hormones (TSH, FT3, and FT4) were measured by electrochemiluminescence while Benzophenones (BP-1, BP-2, and BP-3) were detected by LC-MS/MS.

resultsBP-1, BP-2, and BP-3 were detected in 91.9%, 56.5%, and 88.3% of the analyzed samples, respectively. Mean concentrations were 2.250, 0.178, and 2.067 µg/g creatinine for BP-1, BP-2, and BP-3, respectively. Significant negative associations were found between plasma levels of FT3 and urinary concentrations of both BP-1 (β = -0.101) and BP-3 (β = -0.110). Moreover, significant positive associations were recorded between urinary concentrations of both BP-1 and BP-3 and the application of makeup.

conclusionIn conclusion, exposure of pregnant women to Benzophenones may affect levels of thyroid hormones resulting in possible adverse health effects on the mother and the development of the child. Therefore, preventive measures limiting exposure to these EDCs are recommended.

Indexed as

BenzophenonesBiomarkersEndocrine DisruptorsEnvironmental PollutantsThyroid HormonesAdultFemaleHumansPregnancyYoung AdultBenzophenonesBiomarkersEndocrine DisruptorsEnvironmental PollutantsThyroid HormonesBenzophenonesEndocrine disruptorsExposure sourcesPregnancyThyroid hormones

Identifiers

PMID40285926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.