Evidence map›Paper›PMID 40285916›Full record

ArticleDermatology and therapy2025

Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD.

Pedro Mendes-Bastos, Elisavet Lazaridou, Tiago Torres, Charalampos Aggelakopoulos, Ioannis Katsantonis, Pantelis Aronis, Dimitrios Rigopoulos, Filomena Azevedo, Felicidade Santiago, Markos Papakonstantis and 4 more

Abstract read
In one paragraph

Article in Dermatology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pedro Mendes-BastosDermatology Center, Hospital CUF Descobertas, R. Mário Botas, 1998-018, Lisboa, Portugal.
Elisavet Lazaridou2nd Department of Dermatology-Venereology, Aristotle University School of Medicine, "Papageorgiou" General Hospital, Agiou Pavlou 76, Ag. Pavlos 564 29, Thessaloniki, Greece.
Tiago TorresUnidade Local de Saúde de Santo António, Largo do Prof. Abel Salazar, 4099-001, Porto, Portugal.
Charalampos AggelakopoulosDermatology Department, Athens Naval Hospital, Dinokratous 70, 115 21, Athens, Greece.
Ioannis KatsantonisDermatology Department, Tzaneio General Hospital, Zanni & Afentouli, 185 36, Piraeus, Greece.
Pantelis AronisClinic of Dermatology, Hellenic Airforce 251 General Hospital, Panagioti Kanellopoulou 3, 115 25, Athens, Greece.
Dimitrios Rigopoulos1st Department of Dermatology and Venereology, National and Kapodistrian University of Athens School of Medicine, "A. Syggros" Hospital for Skin and Venereal Diseases, Ionos Dragoumi 5, 161 21, Athens, Greece.
Filomena AzevedoUnidade Local de Saúde de São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Felicidade SantiagoUnidade Local de Saúde da Região de Leiria, Hospital de Santo André, R. de Santo André, 2410-197, Leiria, Portugal.
Markos PapakonstantisClinic of Dermatology, 401 General Military Hospital of Athens, Panagioti Kanellopoulou, 115 25, Athens, Greece.
Paulo VarelaUnidade Local de Saúde deGaia e Espinho, R. Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.
Vera S G RibeiroAbbVie, Lda.; Estrada Alfragide 67 Alfrapark, Edifício D, 2610-008, Amadora, Portugal.
Aikaterini KolliaAbbVie Pharmaceuticals S.A, Marinou Antipa 41-45, 141 21, Iraklio, Athens, Greece.ORCID http://orcid.org/0009-0006-6695-5848
Evaggelia Papadavid2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 1 Rimini Street, 124 62, Chaidari, Athens, Greece. papadavev@yahoo.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite significant progress observed in the treatment of atopic dermatitis (AD), a considerable number of patients with severe disease are undertreated and have inadequate symptom control. This may be due to several reasons, such as underestimation of the implications of the disease on patients, families, and society, as well as inconsistent access to effective treatment. The multidimensional disease burden of AD includes other atopic comorbidities, sleep disturbance, and functional impairment and secondary consequences, including neuropsychiatric issues (anxiety and depression) and reduced health-related quality of life.

methodsMEASURE-AD was a global, cross-sectional observational study in adolescents and adults with moderate-to-severe AD, conducted to describe disease burden, treatment patterns, and healthcare resource utilization.

resultsThe results concerning patients from Portugal and Greece indicate moderate-to-severe disease for most of the population with frequent disease flares. The quality of life of both adolescents and adults was greatly affected, mainly owing to itch. One out of five patients perceived that their treatment was not effectively controlling AD. Disease resulted in important out-of-pocket expenses and loss of productivity.

conclusionsUnderstanding and recognizing the complex burden of moderate-to-severe AD is required to encourage and guide changes in public policy for the effective management of patients.

Indexed as

Atopic dermatitisBurden of diseaseExpensesProductivityQuality of lifeSymptom control

Identifiers

PMID40285916
PMCPMC12092850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.