ArticleBiological trace element research2025
Nano Zinc Oxide Restores Gut Barrier Integrity and Modulates Microbiota to Mitigate TNBS-Induced Colitis in Mice.
Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Silymarin and Zinc Oxide Nanoparticles Attenuate Experimental Colon Cancer in Rats Through Crosstalk of miR-192 and β-Catenin Pathways.Biomolecules · 2026Article
- Combined Effects of Nano-Zinc Oxide and Sesame Oil on Growth Performance, Antioxidant Defense, and Mineral Metabolism in Growing Rabbits.Veterinary sciences · 2026Article
- Piezo1 Regulates ZnT1-Mediated Zinc Homeostasis in Ulcerative Colitis.Inflammation · 2026Article
- Zinc gluconate ameliorates antibiotics/PGN-induced intestinal injury via modulating the gut barrier, macrophages immunity and gut microbiota.Frontiers in microbiology · 2026Article
- A Trace Element-Ulcer Map: Decoding Micronutrient-Ulcer Relationships Through Genetic Architecture and Pleiotropy-Aware Inference.Food science & nutrition · 2025Article
- Systemic dysregulation of the gut microenvironment plays a pivotal role in the onset and progression of inflammatory bowel disease.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Inflammatory bowel diseases (IBD) are chronic, relapsing gastrointestinal disorders with complex pathological mechanisms and limited treatment options, caused by various uncertain factors. Zinc plays a crucial role in wound healing, tissue regeneration, and immune responses. While zinc deficiency is common among patients with IBD, the effects of dietary zinc supplementation on the disease course remain unclear. In this study, 125 male C57BL/6 J mice were randomly divided into five groups: a control group (Con), a 2,4,6-trinitrobenzenesulfonic acid (TNBS) induction group, and three zinc supplementation groups receiving 160 ppm, 400 ppm, and 1000 ppm of zinc oxide nanoparticles ( ZnO NPs), respectively. The results showed that dietary supplementation with ZnO NPs significantly alleviated damage to the colonic mucosal epithelial cells and crypts in IBD mice, while effectively reducing the inflammatory response. Furthermore, ZnO NPs helps maintain the quantity and secretion function of goblet cells, restores normal expression levels of tight junction proteins (ZO-1, occludin), and proliferating cell nuclear antigen (PCNA), and preserves the diversity of gut microbiota. Notably, a significant protective effect was observed with dietary zinc supplementation at 160 ppm. These findings suggest that ZnO NPs significantly improves TNBS-induced intestinal inflammatory damage by modulating the gut microbiota, mucus, and mechanical barriers.
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40285830What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.