Evidence map›Paper›PMID 40285684›Full record

ReviewPM & R : the journal of injury, function, and rehabilitation2025

The role of rehabilitation across the continuum of liver disease from cirrhosis to transplantation and beyond: A narrative review.

Laura Malmut, Sarah Eickmeyer, Leslie Rydberg, Jacqueline Neal, Julie Lanphere, Kim Barker

Abstract readReview
In one paragraph

Review in PM & R : the journal of injury, function, and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura MalmutDepartment of Physical Medicine and Rehabilitation, MedStar National Rehabilitation Hospital, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0003-1122-845X
Sarah EickmeyerDepartment of Physical Medicine and Rehabilitation, University of Kansas Medical Center, Kansas City, Kansas, USA.
Leslie RydbergDepartment of Physical Medicine and Rehabilitation and Medical Education, Northwestern University Feinberg School of Medicine and the Shirley Ryan AbilityLab, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-5817-4861
Jacqueline NealPhysical Medicine and Rehabilitation, Jesse Brown VA, Chicago, Illinois, USA.
Julie LanphereRehabilitation Services, Neurosciences Department, Intermountain Health, Murray, Utah, USA.
Kim BarkerDepartment of Physical Medicine and Rehabilitation, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-9453-5641

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe authors' objective with this narrative review is to explore the impact of rehabilitative interventions at each stage of liver disease. TYPE: Narrative review. LITERATURE SURVEY: Literature search conducted in Medline, Embase, and Google Scholar databases. METHODOLOGY: Articles were included if they were identified in one of the three database, written in English, peer-reviewed, and involved human participants without any restrictions on the publication date. Reference lists of these publications were also scrutinized for other articles that might be relevant. Elibigle articles were reviewed to determine whether they met inclusion crtieria. SYNTHESIS: Authors synthesized findings in the eligible articles to create a narrative summary.

conclusionsChronic liver disease is a major cause of morbidity and mortality across the globe. Cirrhosis causes alterations in metabolic and circulatory functions that negatively affect nutritional status and exercise capacity. Frailty is identified in nearly half of patients with advanced liver disease and bears a poor prognosis. Exercise and nutritional interventions improve key components of physical frailty and quality of life in chronic liver disease and after liver transplantation. Early mobility is generally recommended following liver transplantation and deemed to be safe and feasible. Inpatient rehabilitation may be considered in patients who require ongoing daily medical management by a physician, demonstrate a significant functional decline from their baseline, tolerate intensive rehabilitation, and have functional goals that can be addressed by at least two skilled therapies. Rehabilitation is safe and improves outcomes at every stage of liver disease from cirrhosis to following transplantation. This literature review explores the impact of rehabilitative interventions at each stage of liver disease from cirrhosis to transplantation and beyond.

Indexed as

Liver CirrhosisLiver DiseasesLiver TransplantationQuality of LifeHumans

Identifiers

PMID40285684
PMCPMC12560201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.