Evidence map›Paper›PMID 40285658›Full record

ArticlePharmaceutical biology2025

Biologically active withanolides from

Mayuramas Sang-Ngern, Ashley Fukuchi, Tamara P Kondratyuk, Eun-Jung Park, Charles J Simmons, Marisa M Wall, Sam E Lorch, John M Pezzuto, Leng Chee Chang

Abstract read
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In one paragraph

Article in Pharmaceutical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mayuramas Sang-NgernDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI, United States.
Ashley FukuchiDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI, United States.
Tamara P KondratyukDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI, United States.
Eun-Jung ParkDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI, United States.
Charles J SimmonsX-ray Diffraction Laboratory, Department of Chemistry, University of Hawai'i at Hilo, Hilo, HI, United States.
Marisa M WallDaniel K. Inouye U.S. Pacific Basin Agricultural Research Center, Hilo, HI, United States.
Sam E LorchLani ko Honua Berry Farm, Hilo, HI, United States.
John M PezzutoDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI, United States.
Leng Chee ChangDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI, United States.

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
NIGMS NIH HHS P20 GM103466
6 · The paper itself

Abstract

context

objectiveTo study the chemical composition and potential medicinal properties of Poha. MATERIALS AND

methodsThe fresh fruits and aerial parts of Poha were extracted. The isolation of extract yields a novel withanolide (physaperuvin K;

resultsThe structure of

conclusionsThese findings enhance our understanding of Poha's constituents and potential medicinal properties. One of the most bioactive compounds identified in this study, physaperuvin K, is found in edible fruit.

Indexed as

Anti-Inflammatory AgentsPhysalisPlant ExtractsWithanolidesAnimalsDose-Response Relationship, DrugFruitMacrophagesMiceNF-kappa BNitric OxidePlant Components, AerialRAW 264.7 CellsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsNF-kappa BNitric OxidePlant ExtractsTumor Necrosis Factor-alphaWithanolidesanti-inflammatorycape gooseberrygoldenberryNovel and chlorinated withanolidesPhysalis peruvianapoha

Identifiers

PMID40285658
PMCPMC12035931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.