Evidence map›Paper›PMID 40285591›Full record

ArticleAdvanced healthcare materials2025

Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche.

Gunnar B Thompson, Victoria R Barnhouse, Sydney K Bierman, Brendan A C Harley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Gunnar B ThompsonDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID 0000-0003-2139-8700
Victoria R BarnhouseDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Sydney K BiermanDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Brendan A C HarleyDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID 0000-0001-5458-154X

Funding

Gradient Biomaterials to Investigate Niche Regulation of HematopoiesisR01DK099528 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Brendan A. Harley · 2014 to 2026
$4.0M
Synthetic manipulation of engineered perivascular nichesR01CA256481 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HARLEY, BRENDAN A. · 2021 to 2025
$3.4M
Mineralized collagen composite to accelerate craniofacial bone regenerationR01DE030491 · NIDCR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HARLEY, BRENDAN A. · 2021 to 2025
$2.2M
NCI NIH HHS R01 CA256481NIDCR NIH HHS R01 DE030491NIDDK NIH HHS 2 R01 DK099528NIDDK NIH HHS R01 DK099528
6 · The paper itself

Abstract

Hematopoietic stem cell (HSC) fate is shaped by distinct microenvironments termed niches within the bone marrow. Quiescence, expansion, and differentiation are directly and indirectly regulated by complex combinations of cell secretomes, cell-cell interactions, mechanical signals, and metabolic factors including oxygen tension. The perivascular environment in the bone marrow has been implicated in guiding HSC fate. However, bone marrow presents an environment which is hypoxic (≈1-4% O

Indexed as

Biocompatible MaterialsBone MarrowHematopoietic Stem CellsStem Cell NicheAnimalsBone Marrow CellsCell DifferentiationCell HypoxiaHydrogelsMiceMice, Inbred C57BLOxygenBiocompatible MaterialsHydrogelsOxygengelatinhematopoietic stem cellshydrogelhypoxiaperivascular niche

Identifiers

PMID40285591
PMCPMC12118339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.