Evidence map›Paper›PMID 40285563›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Camouflaged Nanozymes with Oxidation-Promoting Activities Triggering Ferroptosis for Radio-Immunotherapy.

Kun Qiao, Yongbiao Huang, Shipeng Ning, Meng Lyu, Jieqiong Xie, Shiyuan Zhang, Xiuxin Lu, Yuan Yu, Wei Jiang, Bo Liu and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Advanced Therapeutic Approach Based on LDHs-Mimetic Oxidoreductase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kun QiaoDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150000, China.
Yongbiao HuangDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Shipeng NingResearch Center of Nanomedicine Technology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
Meng LyuDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Jieqiong XieResearch Center of Nanomedicine Technology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
Shiyuan ZhangDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150000, China.
Xiuxin LuDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150000, China.
Yuan YuDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150000, China.
Wei JiangAcademy of Medical Sciences, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, Henan, 450000, China.
Bo LiuDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Kelong FanCAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.ORCID https://orcid.org/0000-0001-6285-1933
Tong LiuDepartment of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150000, China.

Funding

National Natural Science Foundation of China 82272872National Natural Science Foundation of China 82303500National Natural Science Foundation of China 82303797National Natural Science Foundation of China 82322048National Natural Science Foundation of China 82473348Natural Science Foundation of Heilongjiang Province of China: Distinguished Youth Program JQ2023H004
6 · The paper itself

Abstract

Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop a cancer cell membrane (CM) - coated nanozyme system (MPPC@CM), specifically designed for radioimmunotherapy to address this issue. This innovative system involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows the nanozyme with enhanced tumor-specific targeting capability due to its homing properties. Upon uptake by tumor cells, MPPC@CM catalytically generates O

Indexed as

Breast NeoplasmsFerroptosisImmunotherapyRadioimmunotherapyAnimalsCell Line, TumorFemaleHumansMiceOxidation-ReductionReactive Oxygen SpeciesTumor MicroenvironmentReactive Oxygen Speciesbreast cancerferroptosisnanozymeradioimmunotherapyradioresistance

Identifiers

PMID40285563
PMCPMC12165144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.