ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Constructing Polymetallic Nodes in Metal-Organic Frameworks Enhance Antibacterial of Drug-Resistant Bacteria.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- MOF on HOF NanoFilms for Efficient Bacteria Infected Wound Healing.Advanced healthcare materials · 2026Article
- Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intramolecular noncovalent trans ring restricting free rotation of σ single bond enhances photosynthesis of hydrogen peroxide.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Chromatic-Zone Mapping for Rapid Discovery of Antibacterial Alloys with Nanostructured Surfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Constructing Polymetallic Nodes in Metal-Organic Frameworks Enhance Antibacterial of Drug-Resistant Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The misuse of antibiotics results in the emergence of a large number of drug-resistant bacteria, which leads to huge financial and social burdens. Exploring artificial nanozymes is regarded as a promising candidates for the substitution of antibiotics, but still remain a huge challenge. Herein, a new strategy is reported for constructing polymetallic indium coordination node Metal-organic frameworks (MOFs) (polyIn-BTB) for enhancing the production of reactive oxygen species (ROS), which significantly promote antibacterial activity. Theoretical research reveals that, compared to monometallic indium coordination node MOFs (monoIn-BTB), polyIn-BTB exhibits a stronger electron-donating ability, which can facilitate the efficient production of ROS. Thus, polyIn-BTB shows outstanding antibacterial properties of 87.0% and 92.0% for Methicillin-Resistant Staphylococcus aureus (MRS. aureus) and Escherichia coli (E. coli) respectively, which is significantly higher than that of monoIn-BTB (42% for MRS. Aureus and 50% for E. coli). The in vivo experiments demonstrate that polyIn-BTB accelerates wound healing by killing bacteria and inhibiting the inflammatory response they cause, with a wound healing rate of 98.0% in 8 days. Overall, this work reports a new strategy for constructing polyIn-BTB for enhancing the antibacterial performance, which opens the door to fundamental research on designing the nanozyme with high performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.