ArticleThe International journal of eating disorders2025
Restrained Eating Features and Brain Morphology: A Pediatric Population-Based Study.
Article in The International journal of eating disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Restrained Eating Features and Brain Morphology: A Pediatric Population-Based Study.The International journal of eating disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveAnorexia nervosa, a restrictive eating disorder that is most commonly seen in females, is associated with alterations in gray matter (GM) and white matter (WM) structures. However, little is known about how restrained eating (RE) and the body mass index-standard deviation score (BMI-SDS) are related to brain morphology and whether sex differences exist in the general pediatric population.
methodParticipants were 9-year-old girls and boys (n = 2729) from the population-based Generation R Study. BMI-SDS was calculated by adjusting BMI for sex and age, using Dutch growth curves. RE is measured with the Dutch Eating Behavior Questionnaire. All children underwent structural magnetic resonance imaging, and brain volumes were calculated using FreeSurfer.
resultsBMI-SDS in girls was positively associated with total intracranial volume and several regional brain volumes. In addition, BMI-SDS showed an inverted U-shaped association with total GM and WM. In girls, RE had a positive linear association with total intracranial, WM, and several regional brain volumes, corrected for BMI-SDS. Additionally, there was an inverted U-shaped association with the amygdala and insula volume. In boys, we found merely positive linear associations between BMI-SDS and brain volumes, and no associations between RE and brain volumes. DISCUSSION: Associations between BMI and brain volumes exist in typically developing children, but there are significant sex differences in the magnitude and shape of the associations. RE is associated with some differences in brain volumes in girls only. Longitudinal studies are needed to assess these associations over a longer period of time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.