Evidence map›Paper›PMID 40285453›Full record

ArticleActa biochimica et biophysica Sinica2025

Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis.

Fen Tan, Juan Chen, Lunquan Sun, Lu Zhang, Rui Zhou

Abstract read
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Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fen TanDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
Juan ChenDepartment of Pulmonary and Critical Care Medicine, Shenzhen People's Hospital, Shenzhen 518020, China.
Lunquan SunCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Lu ZhangDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Rui ZhouDepartment of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha 410011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Connexins (Cxs), also known as gap junction proteins, are structurally related transmembrane proteins and have been implicated in carcinogenesis. Although some evidence suggests that these proteins are tumor suppressors due to their reduced expression in cancers, recent research indicates their complicated roles in tumor progression during different stages, including metastasis. Here, we show that Cx58, which is upregulated in non-small cell lung cancer (NSCLC), is modulated by myocyte-enhancer binding factor 2B (MEF2B). Either

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsMEF2 Transcription FactorsAnimalsCell Line, TumorCell MovementCytoskeletonGene Expression Regulation, NeoplasticHumansMiceMice, NudeNeoplasm InvasivenessNeoplasm MetastasisMEF2B protein, humanMEF2 Transcription Factorsconnexin58MEF2BmetastasisNSCLC

Identifiers

PMID40285453
PMCPMC12368521

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.