Evidence map›Paper›PMID 40285451›Full record

ArticlePhysiological reports2025

Effects of an astaxanthin-containing supplement on oxidative status in skeletal muscle and circulation during deconditioning and reconditioning periods in polo ponies.

Mia Y Kawaida, Oh Sung Kwon, Ahram Ahn, Amanda S Reiter, Nicole M Tillquist, Sung Gi Noh, Jung W Lee, Timothy E Moore, Sarah A Reed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mia Y KawaidaDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.
Oh Sung KwonDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut, USA.
Ahram AhnDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut, USA.
Amanda S ReiterDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.
Nicole M TillquistDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0001-8596-5335
Sung Gi NohDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut, USA.
Jung W LeeDepartment of Statistics, University of Connecticut, Storrs, Connecticut, USA.
Timothy E MooreStatistical Consulting Services, Center for Open Research Resources & Equipment, University of Connecticut, Storrs, Connecticut, USA.
Sarah A ReedDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0002-9961-6280

Funding

University of Connecticut Research Excellence Program
6 · The paper itself

Abstract

This study investigated the effects of astaxanthin (ASTX) supplementation on oxidative status during a deconditioning-reconditioning cycle. Twelve polo ponies were assigned to no supplementation (CON) or an ASTX supplemented group, which received oral administration of a supplement containing 75 mg ASTX daily for 32 weeks. Polo ponies underwent a 16-week deconditioning period (DECON) followed by a 16-week reconditioning program (RECON). Submaximal exercise tests (SETs) were performed at the beginning of the study (Baseline), after DECON, and after RECON. Blood samples were collected at -30, 0, 15, 30, and 60 min relative to each SET for oxidative status analysis. Muscle samples were collected 2 weeks before (Pre-Ex) and 2 h after (Post-Ex) each SET for muscle oxidative status and gene expression analyses. Pre-Ex muscles were analyzed for high-resolution respirometry. Circulating glutathione peroxidase (GPX) activity was increased (p ≤ 0.02) and protein carbonylation was decreased in ASTX (p ≤ 0.05). Muscle oxidative status was affected by DECON and reconditioning (p ≤ 0.05). ASTX increased gene expression of PPARGC1A after reconditioning (p ≤ 0.05). Deconditioning reduced oxidative phosphorylation at complex I and II (p = 0.01). Thus, a deconditioning-reconditioning cycle had greater impacts on muscle oxidative capacity than ASTX supplementation.

Indexed as

AntioxidantsDietary SupplementsMuscle, SkeletalOxidative StressPhysical Conditioning, AnimalAnimalsGlutathione PeroxidaseHorsesMaleXanthophyllsAntioxidantsastaxanthineGlutathione PeroxidaseXanthophyllsastaxanthindeconditioningmitochondriaoxidative statusreconditioning

Identifiers

PMID40285451
PMCPMC12032451

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.