ReviewSensors (Basel, Switzerland)2025
Early Detection and Monitoring of Nephrolithiasis: The Potential of Electrochemical Sensors.
Review in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Application of Nanomaterials in Kidney Stone Disease: Emerging Strategies for Early Diagnosis, Targeted Therapy, and Prevention.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nephrolithiasis (kidney stone disease) continues to pose a significant global health challenge, affecting millions of individuals and placing substantial economic pressures on healthcare systems. Traditional diagnostic methods-such as computed tomography (CT), ultrasound, and basic urinalysis-are often limited by issues including radiation exposure, lower sensitivity in detecting small stones, operator dependency, and the inability to provide real-time analysis. In response, electrochemical sensors have emerged as innovative and powerful tools capable of the rapid, sensitive, and specific detection of key biomarkers associated with nephrolithiasis. This review highlights the advances in electrochemical approaches for monitoring oxalate and uric acid, the two primary metabolites implicated in kidney stone formation. We discuss the principles of electrode design and fabrication, including nanomaterial integration, 3D printing, and molecular imprinting, which have markedly improved detection limits and selectivity. Furthermore, we critically evaluate the practical challenges-such as sensor fouling, reproducibility, and stability in complex biological matrices-that currently impede widespread clinical implementation. The potentials for miniaturization and point-of-care integration are emphasized, with an eye toward continuous or home-based monitoring systems that can offer personalized insights into risk of stone formation and progression. By consolidating recent findings and exploring future trends in multi-analyte detection and wearable diagnostics, this review provides a roadmap for translating electrochemical sensors from research laboratories to routine clinical practice, ultimately aiming to enhance early intervention and improve patient outcomes in nephrolithiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.