Evidence map›Paper›PMID 40285020›Full record

ReviewViruses2025

Clinical Manifestations of Hemorrhagic Fever with Renal Syndrome, Various Nosologic Forms and Issues of Hantavirus Infections Terminology.

Evgeniy Tkachenko, Tamara Dzagurova, Guzel Galieva, Victoria Ivanis, Svetlana Kurashova, Petr Tkachenko, Alexandra Balkina, Dmitriy Trankvilevsky, Aydar Ishmukhametov

Abstract readReview
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Diagnostic and Clinical Challenges of Hantavirus-Associated Acute Kidney Injury.European journal of case reports in internal medicine · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Evgeniy TkachenkoChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Institute of Poliomyelitis, Moscow 108819, Russia.
Tamara DzagurovaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Institute of Poliomyelitis, Moscow 108819, Russia.
Guzel GalievaDepartment of Faculty Therapy, Bashkir State Medical University, Ufa 450008, Russia.
Victoria IvanisDepartment of Infectious Diseases, Pacific State Medical University (PSMU), Vladivostok 690990, Russia.
Svetlana KurashovaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Institute of Poliomyelitis, Moscow 108819, Russia.
Petr TkachenkoDepartment of Internal Disease Propaedeutics, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
Alexandra BalkinaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Institute of Poliomyelitis, Moscow 108819, Russia.
Dmitriy TrankvilevskyDepartment of Epidemiological Surveillance, Federal Center of Hygiene and Epidemiology, Moscow 117105, Russia.ORCID 0000-0002-4896-9369
Aydar IshmukhametovChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Institute of Poliomyelitis, Moscow 108819, Russia.

Funding

Chumakov FSC R&D IBP RAS (Institute of Poliomyelitis) fundamental research assignment 424
6 · The paper itself

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is the result of acute, zoonotic, natural foci hantavirus infections. It has serious social and medical importance due to its widespread distribution and the disease's severity. There is a lack of effective etiotropic therapy and specific prophylaxis available. The aim of this review is to observe the etiological, clinical, and epidemiological features of nosologic HFRS forms in Russia, as well as differences and similarities with hantavirus pulmonary syndrome (HPS). The various clinical HFRS manifestations characterized diseases associated with Puumala, Kurkino, and Sochi hantaviruses in the Russian European part, and with Hantaan, Amur, and Seoul hantaviruses in the Russian Far East. Differences were observed for HFRS foci types based on biological characteristics and natural host population dynamics. As a result of clinical and epidemiological analysis six nosological forms were established, all of which were classified as "hemorrhagic fever with renal syndrome" according to the WHO's expert recommendation from 1983 year. The study showed comparable taxonomic characteristics and determined the mechanism of human infection course for HFRS and HPS. The accumulated knowledge of this study allows for the combination of HFRS and HPS names into a common logical disease name "Hantavirus fever".

Indexed as

Hantavirus InfectionsHemorrhagic Fever with Renal SyndromeOrthohantavirusAnimalsHantavirus Pulmonary SyndromeHumansRussiaTerminology as Topicclinical characteristicsclinical manifestationsepidemiological analysishantaviruseshantavirus pulmonary syndromehemorrhagic fever with renal syndromehot spot infectionnatural hostnosological entitypathogen

Identifiers

PMID40285020
PMCPMC12030865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.