Evidence map›Paper›PMID 40284955›Full record

ReviewViruses2025

E5 Oncoprotein: A Key Player in Human Papillomavirus-Positive Head and Neck Cancer Pathogenesis and Therapy Resistance.

Vanessa Emanuelle Pereira Santos, Bianca de França São Marcos, Pedro Henrique Bezerra Fontes, Micaela Evellin Dos Santos Silva, Stephanie Loureiro Leão, Gabriel Rômulo Parente da Silva, Davi Emanuel Ribeiro, Marco Antonio Turiah Machado da Gama, Beatriz Eda de Oliveira Isídio, Ingrid Andrêssa de Moura and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vanessa Emanuelle Pereira SantosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Bianca de França São MarcosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Pedro Henrique Bezerra FontesLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.ORCID 0000-0001-5609-2977
Micaela Evellin Dos Santos SilvaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.ORCID 0009-0001-0842-4938
Stephanie Loureiro LeãoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Gabriel Rômulo Parente da SilvaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Davi Emanuel RibeiroLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Marco Antonio Turiah Machado da GamaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.ORCID 0000-0001-9739-3100
Beatriz Eda de Oliveira IsídioLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Ingrid Andrêssa de MouraLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.ORCID 0000-0002-0715-8674
David Beltrán LussónLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Lígia Rosa Sales LealLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
Aldo VenutiHPV-Unit, UOSD Tumor Immunology and Immunotherapy IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0003-2322-6857
Antonio Carlos de FreitasLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.ORCID 0000-0002-4957-9549

Funding

Fundação de Amparo à Ciência e Tecnologia de Pernambuco APQ-0806-2.02/24National Council for Scientific and Technological Development 308684/2023-0National Council for Scientific and Technological Development 444156/2023-2National Council for Scientific and Technological Development 444606/2023-8
6 · The paper itself

Abstract

Head and neck cancer (HNC) is the sixth most prevalent type of cancer worldwide and is associated with low five-year survival rates. Alcoholism and smoking are the main risk factors associated with the development of head and neck cancer (HNC). However, Human Papillomavirus (HPV) infection has been reported as a significant risk factor, particularly for the oropharyngeal subset. In these cases, patients with HPV-positive HNC exhibit a better clinical prognosis; however, resistance to chemotherapy has been frequently reported. The carcinogenic activity of HPV is related to the viral oncoproteins E5, E6, and E7. E5 has been associated with immune evasion mechanisms and modulation of the tumor microenvironment, which appears to be linked to the virus's resistance to chemotherapeutic treatments. Here, we review the potential of HPV E5 in targeted therapy for HNC and discuss relevant data regarding the activity of this oncoprotein in head and neck carcinogenesis.

Indexed as

Drug Resistance, NeoplasmHead and Neck NeoplasmsOncogene Proteins, ViralPapillomaviridaePapillomavirus InfectionsHuman Papillomavirus VirusesHumansTumor MicroenvironmentOncogene Proteins, ViralHNChuman papillomavirusimmune evasiononcoproteintumor microenvironment

Identifiers

PMID40284955
PMCPMC12031384

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.