Evidence map›Paper›PMID 40284943›Full record

ArticleViruses2025

Severe Acute Respiratory Syndrome Coronavirus 2 Variant Infection Dynamics and Pathogenesis in Transgenic K18-h

Hongwei Liu, Brianna M Ramirez, Talia S Wong, Christopher M Weiss, Kevin C K Lloyd, Qizhi Gong, Lark L Coffey

Abstract read

In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hongwei LiuDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

Brianna M RamirezDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-4313-9489

Talia S WongDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-1986-6109

Christopher M WeissDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0003-4704-9533

Kevin C K LloydMouse Biology Program, University of California, Davis, CA 95616, USA.

Qizhi GongDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-7453-6508

Lark L CoffeyDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-0718-5146

Funding

UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026

$29.2M

Investigation of Inflammatory Responses in the Olfactory SystemR01DC019769 · NIDCD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Qizhi Gong · 2022 to 2026

$3.5M

NIDCD NIH HHS R01 DC019769NIH HHS U42 OD012210US National Institute of Health Office of the Director DCM/ORIP/Division of Program Coordination, Planning, and Strategic Initiatives U42OD012210

6 · The paper itself

Abstract

The global impact of the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), persists in part due to the emergence of new variants. Understanding variant-specific infection dynamics and pathogenesis in murine models is crucial for identifying phenotypic changes and guiding the development of countermeasures. To address the limitations of earlier studies that investigated only a few variants or used small sample sizes, we evaluated clinical disease, infection kinetics, viral titers, cellular localization, and histopathologic changes in the lungs and brains of transgenic B6.Cg-Tg(K18-

Indexed as

COVID-19Peptidyl-Dipeptidase ASARS-CoV-2Angiotensin-Converting Enzyme 2AnimalsBrainDisease Models, AnimalFemaleHumansLungMaleMiceMice, Inbred C57BLMice, TransgenicViral LoadACE2 protein, humanAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase AC57BL/6J miceCOVID-19human ACE2 receptor-expressing miceinfection dynamicsK18 micemouse modelpathogenesisSARS-CoV-2transgenic mice

Identifiers

PMID40284943

DOI10.3390/v17040500

PMCPMC12031173

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.