ArticleMicroorganisms2025
Carbonate Buffer Mixture Alleviates Subacute Rumen Acidosis Induced by Long-Term High-Concentrate Feeding in Dairy Goats by Regulating Rumen Microbiota.
Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
This study aimed to elucidate the therapeutic mechanisms of carbonate buffer mixture (CBM) in mitigating subacute rumen acidosis (SARA) by examining its effects on rumen pH, systemic inflammation, and rumen microbiota in a dairy goat model. Using a controlled experimental design, SARA was induced through 8-week high-concentrate diet feeding (70% concentrate, 30% forage), followed by 2-day CBM treatment. Comprehensive analyses included rumen pH monitoring, serum inflammatory marker quantification (IL-1β, TNF-α) by ELISA, rumen barrier integrity assessment through tight junction proteins (TJs) ZO-1, Occludin, and Claudin-3 by western blot analysis, and 16S rRNA sequencing of rumen microbiota. The results demonstrated that CBM administration rapidly elevated depressed rumen pH within 6 h post-treatment while concurrently reducing circulating LPS levels. The analysis of rumen 16S rRNA showed that CBM significantly increased the rumen microbial diversity and abundance of SARA dairy goats. Butyric acid generation groups such as
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