Evidence map›Paper›PMID 40284763›Full record

ReviewMicroorganisms2025

The Strategy and Application of Gene Attenuation in Metabolic Engineering.

Yahui Zhang, Zhaoxia Jin, Linxia Liu, Dawei Zhang

Abstract readReview
In one paragraph

Review in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yahui ZhangSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China.
Zhaoxia JinSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China.
Linxia LiuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Dawei ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.ORCID 0000-0002-5857-394X

Funding

International Partnership Program of the Chinese Academy of Sciences 306GJHZ2023019GCNational Key R&D Program of China 2022YFC2106100National Natural Science Foundation of China 22178372National Natural Science Foundation of China 32200049the National Science Fund for Distinguished Young Scholars 22325807
6 · The paper itself

Abstract

Metabolic engineering has a wide range of applications, spanning key sectors such as energy, pharmaceuticals, agriculture, chemicals, and environmental sustainability. Its core focus is on precisely modulating metabolic pathways to achieve efficient, sustainable, and environmentally friendly biomanufacturing processes, offering new possibilities for societal sustainable development. Gene attenuation is a critical technique within metabolic engineering, pivotal in optimizing metabolic fluxes and improving target metabolite yields. This review article discusses gene attenuation mechanisms, the applications across various biological systems, and implementation strategies. Additionally, we address potential future challenges and explore its potential to drive further advancements in the field.

Indexed as

gene attenuationgene regulationmetabolic engineeringmetabolic pathway

Identifiers

PMID40284763
PMCPMC12029929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.