Evidence map›Paper›PMID 40284523›Full record

ReviewPharmaceutics2025

New Direction in Antimicrobial Delivery System: Preparation and Applications of Hydrogel Microspheres.

Jiapeng Li, Guotao Wei, Yihao Yuan, Ling Wang, Miaohan Qiu, Bo Li, Ruofei Ma, Jiawei Wu, Ziyi Shen

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. How PLGA Microspheres are Emerging as a Key Drug Delivery System.International journal of nanomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiapeng LiKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.
Guotao WeiKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.
Yihao YuanKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.
Ling WangKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.
Miaohan QiuCollege of Integrated Traditional Chinese and Western Medicine, Shaanxi University of Chinese Medicine, No.1 Century Avenue Middle Section, Xianyang 712046, China.
Bo LiKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.
Ruofei MaThe First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China.
Jiawei WuKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.
Ziyi ShenKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Science & Medicine, Northwest University, 229 North Taibai Road, Beilin District, Xi'an 710069, China.

Funding

Natural Science Basis Research Plan in Shaanxi Province of China 2023-JC-QN-0824Shaanxi Fundamental Science Research Project for Chemistry & Biology 23JHQ064
6 · The paper itself

Abstract

Antimicrobial delivery systems have undergone extensive development, yet conventional carriers still exhibit limitations such as low loading capacity, inadequate controlled release mechanisms, and cytotoxicity. Recent studies have increasingly demonstrated the potential of Hydrogel Microspheres (HMSs) for antimicrobial delivery. These microspheres exhibit small dimensions, high drug-loading capacity, and the ability to achieve deep-targeted delivery, complemented by adjustable physicochemical properties and biocompatibility that create favorable conditions for antimicrobial transportation. This review systematically examines HMS preparation strategies, characteristic properties, transported antimicrobials, and therapeutic applications. Particular emphasis is placed on critical preparation parameters governing HMS performance, especially those influencing drug delivery dynamics. We conclude by addressing current challenges and proposing actionable strategies for material optimization and clinical translation. This work aims to advance HMS-based antimicrobial delivery systems for more effective infection control.

Indexed as

antimicrobialbiomaterialsdrug releasehydrogel microspherespolymertissue engineering

Identifiers

PMID40284523
PMCPMC12030283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.