Evidence map›Paper›PMID 40284520›Full record

ArticlePharmaceutics2025

Development of an Ophthalmic Hydrogel to Deliver MG53 and Promote Corneal Wound Healing.

Heather L Chandler, Sara Moradi, Spencer W Green, Peng Chen, Christopher Madden, Luxi Zhang, Zhentao Zhang, Ki Ho Park, Jianjie Ma, Hua Zhu and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. BRD4 inhibition mitigates acute and chronic corneal injury following topical nitrogen mustard exposure.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heather L ChandlerCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-7804-1852
Sara MoradiDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-4373-9986
Spencer W GreenDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Peng ChenDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Christopher MaddenCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.
Luxi ZhangCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0005-2153-2836
Zhentao ZhangDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0002-7260-1281
Ki Ho ParkDivision of Surgical Sciences, Department of Surgery, University of Virginia Medical School, Charlottesville, VA 22903, USA.
Jianjie MaDivision of Surgical Sciences, Department of Surgery, University of Virginia Medical School, Charlottesville, VA 22903, USA.
Hua ZhuDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0001-7136-7326
Katelyn E Swindle-ReillyDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1739-0263

Funding

The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP)P30EY032857 · NEI · OHIO STATE UNIVERSITY · PI Sayoko E Moroi · 2022 to 2026
$3.6M
First Aid Medicine to Treat Vesicant Induced Corneal InjuryU01EY032973 · NEI · OHIO STATE UNIVERSITY · PI Heather Chandler, Jianjie Ma · 2022 to 2026
$3.1M
Predictive Drug Release from a Tunable Injectable CapsuleR01EB032870 · NIBIB · OHIO STATE UNIVERSITY · PI Nagaraj Kerur · 2023 to 2026
$2.1M
Inhibiting neovascularization for corneal wound healingR01EY032583 · NEI · OHIO STATE UNIVERSITY · PI CHANDLER, HEATHER, ZHU, HUA · 2022 to 2024
$1.2M
NEI NIH HHS P30 EY032857NEI NIH HHS R01 EY032583NEI NIH HHS U01 EY032973NIBIB NIH HHS R01 EB032870NIH HHS 1R01EY032583-03A1NIH HHS 1R01EY036243-01A1NIH HHS 1U01EY032973-02A1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

corneal opacificationMG53thermosensitive hydrogelvascularization

Identifiers

PMID40284520
PMCPMC12030682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.