ArticlePharmaceutics2025
Population Pharmacokinetic Modeling of Total and Unbound Pamiparib in Glioblastoma Patients: Insights into Drug Disposition and Dosing Optimization.
Charuka Wickramasinghe, Seongho Kim, Yuanyuan Jiang, Xun Bao, Yang Yue, Jun Jiang, Amy Hong, Nader Sanai, Jing Li
Abstract read
In one paragraphArticle in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Charuka WickramasingheKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.ORCID 0009-0007-8002-0632 Seongho KimKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.ORCID 0000-0003-1120-073X Yuanyuan JiangKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Xun BaoKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Yang YueKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Jun JiangKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Amy HongBarrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix, AZ 85013, USA.ORCID 0000-0003-2428-168X Nader SanaiBarrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix, AZ 85013, USA.
Jing LiKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.ORCID 0000-0002-9924-1386 Funding
Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4MPhysiologically Based Pharmacokinetic Modeling of Drug Penetration into the Human Brain and Brain TumorsR01CA255124 · NCI · WAYNE STATE UNIVERSITY · PI LI, JING, SANAI, NADER · 2021 to 2025
$1.9MNCI NIH HHS P30 CA022453NCI NIH HHS R01 CA255124NCI NIH HHS R01CA255124
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
dosing optimizationglioblastomapamiparibPARP inhibitorpopulation pharmacokinetic modelunbound plasma concentrations
Identifiers
PMID40284519
PMCPMC12030534
What OpenQuestion holds
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LicenceCC BY
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